Background The efficacy of simvastatin in critically ill patients with coronavirus disease 2019
(Covid-19) is unclear. Methods In an ongoing international, multifactorial, adaptive platform …

The current epidemic of corona virus disease (COVID-19) has resulted in an immense
health burden that became the third leading cause of death and potentially contributed to a …

The renin–angiotensin system (RAS) plays a crucial role in regulating blood pressure and
the cardio-renal system. The classical RAS, mainly mediated by angiotensin I, angiotensin …

Recent clinical and research efforts in cardiogenic shock (CS) have largely focussed on the
restoration of the low cardiac output state that is the conditio sine qua non of the clinical …

The renin-angiotensin system (RAS) is one of the biggest challenges of cardiovascular
medicine. The significance of the RAS in the chronic progression of SARS-CoV-2 infection …

Background The physiological effects of renin-angiotensin system modulation in acute
respiratory distress syndrome (ARDS) remain controversial and have not been investigated …

ACE2's impact on the severity of COVID-19 is widely discussed but still controversial. To
estimate its role in aspects of the main risk factors and comorbidities, we involved post …

BACKGROUND The efficacy of simvastatin in critically ill patients with coronavirus disease
2019 (Covid-19) is unclear. METHODS In an ongoing international, multifactorial, adaptive …

Background and aims Randomized controlled trials (RCTs) have assessed the effects of
renin–angiotensin system (RAS) blockers in adults with coronavirus disease 2019 (COVID …

As durable learning research systems, adaptive platform trials represent a transformative
new approach to accelerating clinical evaluation and discovery in critical care. This …