Towards a model of GCN2 activation

GR Masson - Biochemical Society Transactions, 2019 - portlandpress.com
Cells must be able to sense and adapt to their surroundings to thrive in a dynamic
environment. Key to adapting to a low nutrient environment is the Integrated Stress …

Selective regulation in ribosome biogenesis and protein production for efficient viral translation

HJ Dong, R Zhang, Y Kuang, XJ Wang - Archives of Microbiology, 2021 - Springer
As intracellular parasites, viruses depend heavily on host cell structures and their functions
to complete their life cycle and produce new viral particles. Viruses utilize or modulate …

Chromosome clustering by Ki-67 excludes cytoplasm during nuclear assembly

S Cuylen-Haering, M Petrovic… - Nature, 2020 - nature.com
Gene expression in eukaryotes requires the effective separation of nuclear transcription and
RNA processing from cytosolic translation. This separation is achieved by the nuclear …

UL3 mediated nucleolar stress pathway as a new mechanism of action of antiproliferative G-quadruplex TBA derivatives in colon cancer cells

A Pecoraro, A Virgilio, V Esposito, A Galeone, G Russo… - Biomolecules, 2020 - mdpi.com
The antiproliferative G-quadruplex aptamers are a promising and challenging subject in the
framework of the anticancer therapeutic oligonucleotides research field. Although several …

[HTML][HTML] Cell surface expression of HLA I molecules as a marker of young platelets

C Angénieux, A Dupuis, C Gachet, H de la Salle… - Journal of Thrombosis …, 2019 - Elsevier
Background Accurate identification of the proportion of young platelets is important to
distinguish peripheral thrombocytopenia from a deficit in platelet production. Young platelets …

Ribosomal protein uL11 as a regulator of metabolic circuits related to aging and cell cycle

M Mołoń, E Molestak, M Kula-Maximenko, P Grela… - Cells, 2020 - mdpi.com
Aging is a biological phenomenon common to all living organisms. It is thought that the rate
of aging is influenced by diverse factors, in many cases related to the control of energy …

[HTML][HTML] The Beak of Eukaryotic Ribosomes: Life, Work and Miracles

S Martín-Villanueva, CV Galmozzi… - …, 2024 - ncbi.nlm.nih.gov
Ribosomes are not totally globular machines. Instead, they comprise prominent structural
protrusions and a myriad of tentacle-like projections, which are frequently made up of …

[HTML][HTML] Structural, topological, and functional characterization of transmembrane proteins TMEM213, 207, 116, 72 and 30B provides a potential link to ccRCC etiology

J Wesoly, N Pstrąg, K Derylo… - American Journal of …, 2023 - ncbi.nlm.nih.gov
Due to their involvement in the development of various cancers Transmembrane Proteins
(TMEMs) are the focus of many recent studies. Previously we reported TMEM de-regulation …

Intraphagolysosomal conditions predispose to Staphylococcus epidermidis small colony variants persistence in macrophages

A Magryś, K Deryło, A Bogut, A Olender… - PLoS …, 2018 - journals.plos.org
Staphylococcus epidermidis small colony variants can survive inside macrophages and their
survival has been proposed as a pivotal process in the pathogenesis of biomaterial …

Phosphorylation of the N‐terminal domain of ribosomal P‐stalk protein uL10 governs its association with the ribosome

K Filipek, B Michalec‐Wawiórka, A Boguszewska… - FEBS …, 2020 - Wiley Online Library
The uL10 protein is the main constituent of the ribosomal P‐stalk, anchoring the whole stalk
to the ribosome through interactions with rRNA. The P‐stalk is the core of the GTPase …