The integrated stress response (ISR) is an evolutionarily conserved intra-cellular signaling
network which is activated in response to intrinsic and extrinsic stresses. Various stresses …

Intrinsically disordered proteins (IDPs) do not have a well-defined structure under
physiological conditions, but they have key roles in cell signaling and regulation, and they …

Ferroptosis is a type of iron-dependent regulated cell death, representing an emerging
disease-modulatory mechanism. Transcription factors play multiple roles in ferroptosis …

Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide,
however our understanding of cell specific mechanisms underlying COPD pathobiology …

Hyperactive and damaging inflammation is a hallmark of severe rather than mild
Coronavirus disease 2019 (COVID-19). To uncover key inflammatory differentiators between …

Ferroptosis is an iron-dependent cell death characterized by the accumulation of
hydroperoxided phospholipids. Here, we report that the NUPR1 inhibitor ZZW-115 induces …

Intrinsically disordered proteins (IDPs) are emerging as attractive drug targets by virtue of
their prevalence in various diseases including cancer. Drug development targeting IDPs is …

Simple Summary Nuclear protein 1 (NUPR1) is activated in cellular stress and is expressed
at high levels in cancer cells. Much evidence has been gathered supporting its critical role in …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with high metastasis
and therapeutic resistance. Activating transcription factor 4 (ATF4), a master regulator of …

Pancreatic fibrosis is caused by the excessive deposits of extracellular matrix (ECM) and
collagen fibers during repeated necrosis to repair damaged pancreatic tissue. Pancreatic …