High‐grade brain tumors are heterogeneous with respect to the composition of bona fide
tumor cells and with respect to a range of intermingling parenchymal cells. Glioblastomas …

Allergic asthma is a complex and chronic inflammatory disorder which is associated with
airway hyper-responsiveness and tissue remodelling of the airway structure. Although …

Intestinal macrophages, which are thought to orchestrate mucosal inflammatory responses,
have received little investigative attention compared with macrophages from other tissues …

Interleukin (IL)-13 is a key mediator of tissue fibrosis caused by T helper cell type 2
inflammation. We hypothesized that the fibrogenic effects of IL-13 are mediated by …

Allergen-specific immunotherapy has been used for 100 years as a desensitizing therapy for
allergic diseases and represents the potentially curative and specific method of treatment …

It has become evident that tumor-induced immuno-suppressive factors in the tumor
microenvironment play a major role in suppressing normal functions of effector T cells …

Transforming growth factor (TGF)-β1 is a major pluripotential cytokine with a pronounced
immunosuppressive effect and its deficiency results in lethal autoimmunity in mice. However …

Myocardial infarction is the most common cause of cardiac injury and results in acute loss of
a large number of myocardial cells. Because the heart has negligible regenerative capacity …

Targeted mutation of TGFβ1 in mice demonstrated that TGFβ1 is one of the key negative
regulators of immune homeostasis, as its absence leads to activation of a self-targeted …

Is there any reason to write a third book on the topic of oxygen-ozone therapy? The first was
written four years ago for italian physicians, who, for some time, had complained about the …