Gap junction channels facilitate the intercellular exchange of ions and small molecules.
While this process is critical to all multicellular organisms, the proteins that form gap junction …

While gap junctions support the exchange of a number of molecules between neighboring
cells, connexin hemichannels provide communication between the cytosol and the …

Abstract Pannexin 1 (PANX1) is an ATP-permeable channel with critical roles in a variety of
physiological functions such as blood pressure regulation, apoptotic cell clearance and …

ATP and its receptor P2RX7 exert a pivotal effect on antitumor immunity during
chemotherapy-induced immunogenic cell death (ICD). Here, we demonstrated that TNFα …

Microglia are the main resident immune-competent cell type of the central nervous system
(CNS); these cells are highly sensitive to subtle changes in the chemical environment of the …

Inflammasomes are multimeric protein complex that assemble in the cytosol upon microbial
infection or cellular stress. Upon activation, inflammasomes drive the maturation of …

Of the 21 members of the connexin family, 4 (Cx37, Cx40, Cx43, and Cx45) are expressed in
the endothelium and/or smooth muscle of intact blood vessels to a variable and dynamically …

Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-
associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl …

Cardiac connexin-43 (Cx43) creates gap junction channels (GJCs) at intercellular contacts
and hemi-channels (HCs) at the peri-junctional plasma membrane and sarcolemmal …

Ischemia-reperfusion (I/R) injury (IRI), which involves inflammation, vascular permeability,
and edema, remains a major challenge after lung transplantation. Pannexin-1 (Panx1) …