[HTML][HTML] Consequences of spinal cord injury on the sympathetic nervous system

MJ Wulf, VJ Tom - Frontiers in cellular neuroscience, 2023 - frontiersin.org
Spinal cord injury (SCI) caused by a crush, cut, or blow to the spinal cord is a devastating
event that results in permanent functional deficits. SCI damages multiple structures at the …

The effects of extrinsic and intrinsic factors on neurogenesis

M Jiang, SE Jang, L Zeng - Cells, 2023 - mdpi.com
In the mammalian brain, neurogenesis is maintained throughout adulthood primarily in two
typical niches, the subgranular zone (SGZ) of the dentate gyrus and the subventricular zone …

Role of descending serotonergic fibers in the development of pathophysiology after spinal cord injury (SCI): Contribution to chronic pain, spasticity, and autonomic …

GNK Fauss, KE Hudson, JW Grau - Biology, 2022 - mdpi.com
Simple Summary Fiber pathways that descend from the brain to the spinal cord drive motor
behavior and modulate incoming sensory signals and the capacity to change (plasticity). A …

Neuronal transplantation for Alzheimer's disease and prospects for generating exogenic neurons as a source of cells for implantation

P Strell, ST Johnson, C Carchi… - Cell …, 2023 - journals.sagepub.com
Alzheimer's disease (AD) is a devastating neurodegenerative disease with limited
therapeutic options. Cellular transplantation of healthy exogenic neurons to replace and …

Transneuronal tracing to map connectivity in injured and transplanted spinal networks

TA Fortino, ML Randelman, AA Hall, J Singh… - Experimental …, 2022 - Elsevier
It has become widely appreciated that the spinal cord has significant neuroplastic potential,
is not hard-wired, and that with traumatic injury and anatomical plasticity, the networks that …

Spinal cord injury impairs cardiac function due to impaired bulbospinal sympathetic control

MPM Fossey, SJT Balthazaar, JW Squair… - Nature …, 2022 - nature.com
Spinal cord injury chronically alters cardiac structure and function and is associated with
increased odds for cardiovascular disease. Here, we investigate the cardiac consequences …

Restoring neuro-immune circuitry after brain and spinal cord injuries

M Ueno - International Immunology, 2021 - academic.oup.com
Neuro-immune interactions are essential for our body's defense and homeostasis.
Anatomical and physiological analyses have shown that the nervous system comprises …

Cell transplantation to repair the injured spinal cord

A Hall, T Fortino, V Spruance, A Niceforo… - International review of …, 2022 - Elsevier
Spinal cord injuries (SCIs) are life-changing events that often irrevocably alter the lives of
injured individuals and their family members. There are more than 300,000 people living …

Autonomic Dysreflexia in Spinal Cord Injury: Mechanisms and Prospective Therapeutic Targets

CT Trueblood, A Singh, MA Cusimano… - The …, 2023 - journals.sagepub.com
High-level spinal cord injury (SCI) often results in cardiovascular dysfunction, especially the
development of autonomic dysreflexia. This disorder, characterized as an episode of …

The susceptibility of cardiac arrhythmias after spinal cord crush injury in rats

S Fernandes, E Oatman, J Weinberger, A Dixon… - Experimental …, 2022 - Elsevier
High-level spinal cord injury (SCI) often interrupts supraspinal regulation of sympathetic
input to the heart. Although it is known that dysregulated autonomic control increases the …