Abstract N-acetyl cysteine (NAC), as a nutritional supplement, is a greatly applied
antioxidant in vivo and in vitro. NAC is a precursor of L-cysteine that results in glutathione …

In 1907, Alois Alzheimer described the case of a 51 year old woman who presented with a
relatively rapidly deteriorating memory along with psychiatric disturbances. She died four …

This review highlights the properties of nanoparticles used in targeted drug delivery,
including delivery to cells as well as organelle targets, some of the known pharmacokinetic …

Although amyloid‐β peptide (Aβ) is the neurotoxic species implicated in the pathogenesis of
Alzheimer's disease (AD), mechanisms through which intracellular Aβ impairs cellular …

Neurodegenerative diseases share various pathological features, such as accumulation of
aberrant protein aggregates, microglial activation, and mitochondrial dysfunction. These …

There is a great deal of evidence to support a pathogenic role of oxidative stress in
Alzheimer's disease (AD), but the sources of reactive oxygen species have not been directly …

Resveratrol is a polyphenol that is mainly found in grapes and red wine and has been
reported to be a caloric restriction (CR) mimetic driven by Sirtuin 1 (SIRT1) activation …

Immunizing transgenic PDAPP mice, which overexpress mutant APP and develop β‐
amyloid deposition resembling plaques in Alzheimer's disease (AD), results in a decrease of …

Nrf2, a redox sensitive transcription factor, plays a pivotal role in redox homeostasis during
oxidative stress. Nrf2 is sequestered in cytosol by an inhibitory protein Keap1 which causes …

More people die from cardiovascular diseases (CVD) than from any other cause.
Cardiovascular complications are thought to arise from enhanced levels of free radicals …