In the past century, considerable efforts were made to understand the role of mitochondrial
DNA (mtDNA) mutations and of oxidative stress in aging. The classic mitochondrial free …

Cardiovascular diseases (CVDs) are serious public health issues and are responsible for
nearly one-third of global deaths. Mitochondrial dysfunction is accountable for the …

Decline in human muscle mass and strength (sarcopenia) is a hallmark of the aging
process. A growing body of research in the areas of bioenergetics and protein turnover has …

AMP-activated protein kinase (AMPK) is a fundamental regulator of energy metabolism,
stress resistance, and cellular proteostasis. AMPK signaling controls an integrated signaling …

Aging is an inevitable biological process and is accompanied by a gradual decline of
physiological functions, such as the incidence of age-related diseases. Aging becomes a …

AMP-activated protein kinase (AMPK) is a key regulator of metabolism and survival during
energy stress. Dysregulation of AMPK is strongly associated with oxidative-stress-related …

Resveratrol is a natural polyphenolic stilbene derivative found in several human diet
components that possess important and wide-ranging effects in biological systems including …

Aging-associated muscle insulin resistance has been hypothesized to be due to decreased
mitochondrial function, secondary to cumulative free radical damage, leading to increased …

Aging is associated with an overall loss of function at the level of the whole organism that
has origins in cellular deterioration. Most cellular components, including mitochondria …

The susceptibility of human CD4+ and CD8+ T cells to senesce differs, with CD8+ T cells
acquiring an immunosenescent phenotype faster than the CD4+ T cell compartment. We …