Controlling schistosomiasis with praziquantel: How much longer without a viable alternative?
R Bergquist, J Utzinger, J Keiser - Infectious diseases of poverty, 2017 - Springer
The current approach of morbidity control of schistosomiasis, a helminth disease of poverty
with considerable public health and socioeconomic impact, is based on preventive …
with considerable public health and socioeconomic impact, is based on preventive …
Searching for drugs for Chagas disease, leishmaniasis and schistosomiasis: a review
Chagas disease, leishmaniasis and schistosomiasis are neglected diseases (NDs) and are
a considerable global challenge. Despite the huge number of people infected, NDs do not …
a considerable global challenge. Despite the huge number of people infected, NDs do not …
Antischistosomal agents: state of art and perspectives
EM Lago, RP Xavier, TR Teixeira, LM Silva… - Future Medicinal …, 2018 - Taylor & Francis
Praziquantel has remained the drug of choice for schistosomiasis chemotherapy for almost
40 years. The pressing need to develop a new antischistosomal drug may necessitate …
40 years. The pressing need to develop a new antischistosomal drug may necessitate …
Computational quantum chemistry, molecular docking, and ADMET predictions of imidazole alkaloids of Pilocarpus microphyllus with schistosomicidal properties
JA Rocha, NCS Rego, BTS Carvalho, FI Silva… - PloS one, 2018 - journals.plos.org
Schistosomiasis affects million people and its control is widely dependent on a single drug,
praziquantel. Computational chemistry has led to the development of new tools that predict …
praziquantel. Computational chemistry has led to the development of new tools that predict …
Brazilian red propolis exhibits antiparasitic properties in vitro and reduces worm burden and egg production in an mouse model harboring either early or chronic …
MP Silva, TM Silva, AC Mengarda, MC Salvadori… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Propolis has been used in folk medicine for thousands of
years and, in the past few decades, it has attracted renewed interest. Although propolis has …
years and, in the past few decades, it has attracted renewed interest. Although propolis has …
Antiparasitic activity of piplartine (piperlongumine) in a mouse model of schistosomiasis
Schistosomiasis is one of the most important parasitic infections in terms of its negative
effects on public health and economics. Since praziquantel is currently the only drug …
effects on public health and economics. Since praziquantel is currently the only drug …
[PDF][PDF] Bioactive Compounds and Antischistosomal Activity of Dolichos Species: A Review
NM Musa, MS Sallau, AO Oyewale, T Ali - J. Chem. Rev, 2023 - researchgate.net
This review focuses on the isolated bioactive compounds and antischistosomal activity of
Dolichos species, particularly Dolichos biflorus and Dolichos lablab. Medicinal plants have …
Dolichos species, particularly Dolichos biflorus and Dolichos lablab. Medicinal plants have …
Pyrazoline derivatives as promising novel antischistosomal agents
CS Morais, AC Mengarda, FB Miguel, KB Enes… - Scientific Reports, 2021 - nature.com
Praziquantel is the only available drug to treat schistosomiasis, a parasitic disease that
currently infects more than 240 million people globally. Due to increasing concerns about …
currently infects more than 240 million people globally. Due to increasing concerns about …
Curcumin nanoemulsion as a novel chemical for the treatment of acute and chronic toxoplasmosis in mice
SJ Azami, A Teimouri, H Keshavarz… - International journal …, 2018 - Taylor & Francis
Background The aim of this study was to prepare curcumin nanoemulsion (CR-NE) to solve
the problems associated with poor water solubility and low bioavailability of CR and to test …
the problems associated with poor water solubility and low bioavailability of CR and to test …
In Vitro Assessment of Anthelmintic Activities of Rauwolfia vomitoria (Apocynaceae) Stem Bark and Roots against Parasitic Stages of Schistosoma mansoni and …
EM Tekwu, KM Bosompem, WK Anyan… - Journal of …, 2017 - Wiley Online Library
Schistosomiasis is a Neglected Tropical Diseases which can be prevented with mass
deworming chemotherapy. The reliance on a single drug, praziquantel, is a motivation for …
deworming chemotherapy. The reliance on a single drug, praziquantel, is a motivation for …