Controlling schistosomiasis with praziquantel: How much longer without a viable alternative?

R Bergquist, J Utzinger, J Keiser - Infectious diseases of poverty, 2017 - Springer
The current approach of morbidity control of schistosomiasis, a helminth disease of poverty
with considerable public health and socioeconomic impact, is based on preventive …

Searching for drugs for Chagas disease, leishmaniasis and schistosomiasis: a review

SS Santos, RV de Araújo, J Giarolla, O El Seoud… - International journal of …, 2020 - Elsevier
Chagas disease, leishmaniasis and schistosomiasis are neglected diseases (NDs) and are
a considerable global challenge. Despite the huge number of people infected, NDs do not …

Antischistosomal agents: state of art and perspectives

EM Lago, RP Xavier, TR Teixeira, LM Silva… - Future Medicinal …, 2018 - Taylor & Francis
Praziquantel has remained the drug of choice for schistosomiasis chemotherapy for almost
40 years. The pressing need to develop a new antischistosomal drug may necessitate …

Computational quantum chemistry, molecular docking, and ADMET predictions of imidazole alkaloids of Pilocarpus microphyllus with schistosomicidal properties

JA Rocha, NCS Rego, BTS Carvalho, FI Silva… - PloS one, 2018 - journals.plos.org
Schistosomiasis affects million people and its control is widely dependent on a single drug,
praziquantel. Computational chemistry has led to the development of new tools that predict …

Brazilian red propolis exhibits antiparasitic properties in vitro and reduces worm burden and egg production in an mouse model harboring either early or chronic …

MP Silva, TM Silva, AC Mengarda, MC Salvadori… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Propolis has been used in folk medicine for thousands of
years and, in the past few decades, it has attracted renewed interest. Although propolis has …

Antiparasitic activity of piplartine (piperlongumine) in a mouse model of schistosomiasis

AC Mengarda, PS Mendonca, CS Morais, RM Cogo… - Acta tropica, 2020 - Elsevier
Schistosomiasis is one of the most important parasitic infections in terms of its negative
effects on public health and economics. Since praziquantel is currently the only drug …

[PDF][PDF] Bioactive Compounds and Antischistosomal Activity of Dolichos Species: A Review

NM Musa, MS Sallau, AO Oyewale, T Ali - J. Chem. Rev, 2023 - researchgate.net
This review focuses on the isolated bioactive compounds and antischistosomal activity of
Dolichos species, particularly Dolichos biflorus and Dolichos lablab. Medicinal plants have …

Pyrazoline derivatives as promising novel antischistosomal agents

CS Morais, AC Mengarda, FB Miguel, KB Enes… - Scientific Reports, 2021 - nature.com
Praziquantel is the only available drug to treat schistosomiasis, a parasitic disease that
currently infects more than 240 million people globally. Due to increasing concerns about …

Curcumin nanoemulsion as a novel chemical for the treatment of acute and chronic toxoplasmosis in mice

SJ Azami, A Teimouri, H Keshavarz… - International journal …, 2018 - Taylor & Francis
Background The aim of this study was to prepare curcumin nanoemulsion (CR-NE) to solve
the problems associated with poor water solubility and low bioavailability of CR and to test …

In Vitro Assessment of Anthelmintic Activities of Rauwolfia vomitoria (Apocynaceae) Stem Bark and Roots against Parasitic Stages of Schistosoma mansoni and …

EM Tekwu, KM Bosompem, WK Anyan… - Journal of …, 2017 - Wiley Online Library
Schistosomiasis is a Neglected Tropical Diseases which can be prevented with mass
deworming chemotherapy. The reliance on a single drug, praziquantel, is a motivation for …