Background: Migraine is a common disabling neurological disorder where attacks have
been recognized to consist of more than headache. The premonitory, headache, and …

An understanding of the pathophysiology of migraine should be based on the anatomy and
physiology of the pain-producing structures of the cranium integrated with knowledge of …

Abstract Background and Objective Erenumab is the first migraine-specific preventive
therapy approved by Health Canada since the approval of onabotulinumtoxinA 10 years …

Migraine is a debilitating neurovascular disorder characterized by recurrent headache
attacks of moderate to severe intensity. Calcitonin gene-related peptide (GGRP), which is …

Following positive phase-III clinical trials, lasmiditan is the first ditan to be FDA-approved.
PACAP has experimental evidence suggesting a role in migraine pathophysiology. As for …

Dystonia is a movement disorder characterized by sustained or intermittent muscle
contractions and its pathophysiological mechanisms are still poorly understood. Dominant …

Background Blocking the pro-nociceptive action of CGRP is one of the most promising
approaches for migraine prophylaxis. The aim of this study was to explore a role for CGRP …

The transient receptor potential ankyrin type-1 (TRPA1) channels have been proposed as a
potential target for migraine therapy. Yet the role of cortical TRPA1 channels in migraine …

The cerebellum is associated with the biology of migraine in a variety of ways. Clinically,
symptoms such as fatigue, motor weakness, vertigo, dizziness, difficulty concentrating and …

Cortical spreading depression (CSD) is the electrophysiological correlate of migraine aura.
Transgenic mice carrying the R192Q missense mutation in the Cacna1a gene, which in …