In biological research, rapid wide-field fluorescence lifetime imaging has become an
important imaging tool. However, the biological samples with weak fluorescence signals and …

Third harmonic generation (THG) microscopy shows great potential for instant pathology of
brain tissue during surgery. However, the rich morphologies contained and the noise …

In this research paper, we attempt to introduce a new algorithm for filtering a state-space
model. The observations of this algorithm follow an exponential dispersion model. The …

We investigate a fast optimization method for determining the minimizer of the negative
Poisson likelihood function for the global analysis of fluorescence lifetime microscopy. Using …

Modern clinical diagnoses and treatments have been increasingly reliant on medical
imaging techniques. In return, medical images are required to provide more accurate and …

Image denoising techniques are important to cope with different types of noise in biomedical
and biometric images. Not only random noise but also general irrelevant components in …

Non-perturbing tools that provide reliable, information-rich assessments of living biological
systems can inform clinical practice and improve patient health. In this dissertation, we …