Alzheimer's disease (AD) is the most common cause of dementia. Epidemiological studies
show the association between AD and type 2 diabetes (T2DM), although the mechanisms …

Background Succinate is produced by both human cells and by gut bacteria and couples
metabolism to inflammation as an extracellular signaling transducer. Circulating succinate is …

ABSTRACT Inflammatory Bowel Disease (IBD) is a chronic immune-mediated inflammatory
disease of the gastrointestinal tract that is a growing public burden. Gut microbes and their …

Objective Ample evidence exists for the role of abnormal gut microbiota composition and
increased gut permeability ('leaky gut') in chronic inflammation that commonly co-occurs in …

Aging-related abnormalities in gut microbiota are associated with cognitive decline,
depression, and anxiety, but underlying mechanisms remain unstudied. Here, our study …

Disclosure summary Dr. Yadav is Chief Scientific Officer and Co-Founder of Postbiotics Inc
and has no conflict of interest with this work. All other authors have no conflicts of interest to …

Short-chain fatty acids (SCFAs) are key nutrients that play a diverse set of roles in
physiological function, including regulating metabolic homeostasis. Generated through the …

The prevalence of type 2 diabetes mellitus (T2D) is increasing worldwide, and there are no
long-term preventive strategies to stop this growth. Emerging research shows that …

Obesity is a disease in which fat is abnormally or excessively accumulated in the body, and
many studies have been conducted to overcome it with various techniques. In this study, we …

Free fatty acid receptor 3 (FFA3) is a recently-deorphanized G-protein-coupled receptor. Its
ligands are short-chain fatty acids (SCFAs), which are key nutrients derived from the gut …