Molecular mechanisms of TDP-43 misfolding and pathology in amyotrophic lateral sclerosis
A Prasad, V Bharathi, V Sivalingam… - Frontiers in molecular …, 2019 - frontiersin.org
TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in
RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as …
RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as …
Physiological functions and pathobiology of TDP‐43 and FUS/TLS proteins
The multiple roles played by RNA binding proteins in neurodegeneration have become
apparent following the discovery of TAR DNA binding protein 43 kDa (TDP‐43) and fused in …
apparent following the discovery of TAR DNA binding protein 43 kDa (TDP‐43) and fused in …
Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects
J Mitra, EN Guerrero, PM Hegde… - Proceedings of the …, 2019 - National Acad Sciences
Genome damage and their defective repair have been etiologically linked to degenerating
neurons in many subtypes of amyotrophic lateral sclerosis (ALS) patients; however, the …
neurons in many subtypes of amyotrophic lateral sclerosis (ALS) patients; however, the …
Disruption of RNA metabolism in neurological diseases and emerging therapeutic interventions
RNA binding proteins are critical to the maintenance of the transcriptome via controlled
regulation of RNA processing and transport. Alterations of these proteins impact multiple …
regulation of RNA processing and transport. Alterations of these proteins impact multiple …
Bridging biophysics and neurology: aberrant phase transitions in neurodegenerative disease
NB Nedelsky, JP Taylor - Nature Reviews Neurology, 2019 - nature.com
Biomolecular condensation arising through phase transitions has emerged as an essential
organizational strategy that governs many aspects of cell biology. In particular, the role of …
organizational strategy that governs many aspects of cell biology. In particular, the role of …
Cytoplasmic functions of TDP-43 and FUS and their role in ALS
TAR DNA-binding protein of 43 kDa (TDP-43) and fused in sarcoma (FUS) are RNA binding
proteins (RBPs) primarily located in the nucleus, and involved in numerous aspects of RNA …
proteins (RBPs) primarily located in the nucleus, and involved in numerous aspects of RNA …
RNA-binding proteins in neurological development and disease
S Prashad, PP Gopal - RNA biology, 2021 - Taylor & Francis
ABSTRACT RNA-binding proteins are a critical group of multifunctional proteins that
precisely regulate all aspects of gene expression, from alternative splicing to mRNA …
precisely regulate all aspects of gene expression, from alternative splicing to mRNA …
RNA metabolism in neurodegenerative disease
EY Liu, CP Cali, EB Lee - Disease models & mechanisms, 2017 - journals.biologists.com
Aging-related neurodegenerative diseases are progressive and fatal neurological diseases
that are characterized by irreversible neuron loss and gliosis. With a growing population of …
that are characterized by irreversible neuron loss and gliosis. With a growing population of …
RNA modifications and RNA metabolism in neurological disease pathogenesis
B Chatterjee, CKJ Shen, P Majumder - International journal of molecular …, 2021 - mdpi.com
The intrinsic cellular heterogeneity and molecular complexity of the mammalian nervous
system relies substantially on the dynamic nature and spatiotemporal patterning of gene …
system relies substantially on the dynamic nature and spatiotemporal patterning of gene …
Structural plasticity of the hippocampus in neurodegenerative diseases
PDE Weerasinghe-Mudiyanselage, MJ Ang… - International journal of …, 2022 - mdpi.com
Neuroplasticity is the capacity of neural networks in the brain to alter through development
and rearrangement. It can be classified as structural and functional plasticity. The …
and rearrangement. It can be classified as structural and functional plasticity. The …