Translational control of mRNAs during gene expression allows cells to promptly and
dynamically adapt to a variety of stimuli, including in neoplasia in response to aberrant …

RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …

Rapamycin, a macrocyclic lactone, is a highly specific inhibitor of the serine/threonine
protein kinase target of rapamycin (TOR). Although it is clear that TOR controls initiation of …

The progression of cancers from primary tumors to invasive and metastatic stages accounts
for the overwhelming majority of cancer deaths. Understanding the molecular events which …

The contribution of the mRNA cap-binding protein, eIF-4E, to malignant transformation and
progression has been illuminated over the past decade. eIF-4E overexpression has been …

The link between perturbations in translational control and cancer etiology is becoming a
primary focus in cancer research. It has now been established that genetic alterations in …

In 2018, 550,000 people were diagnosed with bladder cancer (BC), of which nearly 200,000
people died. Moreover, men are 4 times more likely than women to be diagnosed with BC …

Proteins regulating the mammalian target of rapamycin (mTOR), as well as some of the
targets of the mTOR kinase, are overexpressed or mutated in cancer. Rapamycin, the …

Translational control is a key step in eukaryotic gene expression. The majority of
translational control occurs at the level of initiation, thus implicating the 5′ untranslated …

The mammalian target of rapamycin (mTOR) pathway plays a central role in regulating
protein synthesis, ribosomal protein translation, and cap-dependent translation …