The role of N-methyladenosine modification in acute and chronic kidney diseases

S Qi, J Song, L Chen, H Weng - Molecular Medicine, 2023 - Springer
Abstract N 6-methyladenosine (m6A) modification is a kind of RNA modification in which
methylation occurs at the sixth N position in adenosine in RNA, which can occur in various …

The role of RNA methylation in tumor immunity and its potential in immunotherapy

Y Li, H Jin, Q Li, L Shi, Y Mao, L Zhao - Molecular Cancer, 2024 - Springer
RNA methylation, a prevalent post-transcriptional modification, has garnered considerable
attention in research circles. It exerts regulatory control over diverse biological functions by …

Chirality Regulates Macrophage Polarization for Tissue Regeneration Through Bidirectionally Modulating WTAP‐Mediated m6A Modification

Y Yang, X Guo, C Huang, C Chen, Y Zhou… - Small …, 2024 - Wiley Online Library
Chirality, a fundamental design feature at all levels of life organization, has shown great
capability in guiding cell‐fate determination and tissue regeneration. Chirality‐directed …

[HTML][HTML] Novel insights into the regulatory role of N6-methyladenosine methylation modified autophagy in sepsis

CF Bi, J Liu, XD Hu, LS Yang, JF Zhang - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to infection. It is characterized by high morbidity and mortality and one of the major …

[HTML][HTML] METTL3 Deficiency Aggravates Hepatic Ischemia/Reperfusion Injury in Mice by Activating the MAPK Signaling Pathway

Y Gao, M Wang, R Qin, C Zhao… - International Journal of …, 2024 - ncbi.nlm.nih.gov
Background: Inflammatory responses, apoptosis, and oxidative stress, are key factors that
contribute to hepatic ischemia/reperfusion (I/R) injury, which may lead to the failure of liver …

Specific deletion of Mettl3 in IECs triggers the development of spontaneous colitis and dysbiosis of T lymphocytes in mice

M Fang, J Yao, H Zhang, J Sun, Y Yin… - Clinical and …, 2024 - academic.oup.com
The enzymatic core component of m6A writer complex, Mettl3, plays a crucial role in
facilitating the development and progress of gastric and colorectal cancer (CRC). However …

[HTML][HTML] METTL3-mediated NDUFB5 m6A modification promotes cell migration and mitochondrial respiration to promote the wound healing of diabetic foot ulcer

T Wang, X Li, Y Tao, X Wang… - Journal of …, 2024 - … -medicine.biomedcentral.com
Diabetic foot ulcer (DFU) is the most devastating complication of diabetes mellitus (DM) and
plays a major role in disability and death in DM patients. NADH: ubiquinone oxidoreductase …

METTL3-Mediated N6-methyladenosine mRNA Modification and cGAS-STING Pathway Activity in Kidney Fibrosis

YC Tsai, TH Hsieh, YR Liao, MT Tsai… - Journal of the …, 2024 - journals.lww.com
Background Chemical modifications on RNA profoundly impact RNA function and
regulation. m 6 A, the most abundant RNA modification in eukaryotes, plays a pivotal role in …

Shenqi Qiangjing Granules Ameliorate Asthenozoospermia in Mice by Regulating Ferroptosis through the METTL3/GPX4 Signaling Axis

Q Lu, J Ma, L Wei, J Fu, X Li, K Lai… - … Tohoku journal of …, 2024 - pubmed.ncbi.nlm.nih.gov
Shenqi Qiangjing Granules Ameliorate Asthenozoospermia in Mice by Regulating
Ferroptosis through the METTL3/GPX4 Signaling Axis Shenqi Qiangjing Granules …

WTAP, transcriptionally regulated by p65, promotes inflammation through m6A modification and phase separation

Y Ge, R Chen, T Ling, B Liu, J Huang, Y Cheng, Y Lin… - bioRxiv, 2023 - biorxiv.org
Emerging evidence has linked dysregulation of N 6-methyladenosine (m6A) to inflammation
and inflammatory diseases, but the underlying mechanism still needs investigation. Here …