Adenosine triphosphate (ATP) is one of the main biochemical components of the tumor
microenvironment (TME), where it can promote tumor progression or tumor suppression …

Adenosine 5′-triphosphate acts as an extracellular signalling molecule (purinergic
signalling), as well as an intracellular energy source. Adenosine 5′-triphosphate receptors …

Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

There is nervous control of the heart by ATP as a cotransmitter in sympathetic,
parasympathetic, and sensory-motor nerves, as well as in intracardiac neurons. Centers in …

Extracellular nucleotides, mainly ATP, but also ADP, UTP, UDP and UDP-sugars,
adenosine, and adenine base participate in the “purinergic signalling” pathway, an …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Extracellular nucleotides and nucleosides mediate diverse signaling effects in virtually all
organs and tissues. Most models of purinergic signaling depend on functional interactions …

Purinergic receptors, represented by several families, are arguably the most abundant
receptors in living organisms and appeared early in evolution. After slow acceptance …

Purinergic signaling plays important roles in control of vascular tone and remodeling. There
is dual control of vascular tone by ATP released as a cotransmitter with noradrenaline from …

Abstract Extracellular adenosine 5′-triphosphate (ATP) and adenosine molecules are
intimately involved in immune responses. ATP is mostly a pro-inflammatory molecule and is …