Long non-protein-coding RNAs (lncRNAs) are proposed to be the largest transcript class in
the mouse and human transcriptomes. Two important questions are whether all lncRNAs are …

The two mannose 6-phosphate (M6P) receptors were identified because of their ability to
bind M6P-containing soluble acid hydrolases in the Golgi and transport them to the …

Chromatin regulators have become attractive targets for cancer therapy, but it is unclear why
inhibition of these ubiquitous regulators should have gene-specific effects in tumor cells …

Mammalian imprinted genes often cluster with long noncoding (lnc) RNAs. Three lncRNAs
that induce parental-specific silencing show hallmarks indicating that their transcription is …

Imprinted genes in mammals are expressed from only one of the parental chromosomes,
and are crucial for placental development and fetal growth,,,. The insulin-like growth factor II …

I. Overview T HE general characterization of the growth hormone/insulin-like growth factor-I
(GH/IGF-I) system has been established for a considerable length of time, and we will not …

In genomic imprinting, one of the two parental alleles of an autosomal gene is silenced
epigenetically by a cis-acting mechanism,. A bidirectional silencer for a 400-kilobase region …

The environment in which the fetus develops is critical for its survival and long-term health.
The regulation of normal human fetal growth involves many multidirectional interactions …

It has been a controversial issue as to how many DNA cytosine methyltransferase
mammalian cells have and whether de novo methylation and maintenance methylation …

Little is known about the structure and function of membrane domains in the vacuolar
apparatus of animal cells. A unique feature of late endosomes, which are part of the pathway …