Serotonin is a naturally occurring vasoactive substance that has diverse cardio-
physiological effects. These effects can be explained by the existence of serotonin receptor …

Serotonin, or 5‐hydroxytryptamine, is a naturally‐occurring vasoactive substance found
primarily in the brain, enterochromaffin tissue, and blood platelets. It has diffuse …

Ketanserin is a 5-HT 2 receptor antagonist without partial agonist properties which also
possesses weak α 1-adrenoceptor antagonistic activity, which may explain its …

Ketanserin is an agent whose main pharmacologic action is antagonism of serotonin (5-
hydroxytryptamine, 5HT) receptors of the 5HT2 subtype. It also has weak α1-adrenergic …

Most agree that antihypertensive medication should be used to treat severe hypertension
during pregnancy, but its role in patients with mild to moderate disease is debated. None of …

In a study of the kinetics of 5-hydroxytryptamine (5-HT) in platelets in 26 hypertensive
subjects with a mean systolic and diastolic blood pressure of 153.9±26.9 and 106.9±9.1 mm …

A 65‐year‐old man with arterial hypertension received oral treatment with Ketanserin, a new
drug, during a period of five months. He developed marked QT interval prolongation and …

Competitive α 1-adrenoceptor antagonists are effective in the treatment of both hypertension
and cardiac failure. Prazosin has both a short half-life and a short duration of action, but …

The pharmacokinetics of ketanserin and its main metabolite ketanserin-ol, and the
antihypertensive effects of intravenous, single oral and chronic oral (40 mg once daily) …

Extensive clinical investigation has shown that ketanserin is an effective first‐line
antihypertensive agent with particular advantages in older patients. It has a favorable …