[HTML][HTML] Linking the Amyloid, Tau, and Mitochondrial Hypotheses of Alzheimer's Disease and Identifying Promising Drug Targets

Z Fišar - Biomolecules, 2022 - mdpi.com
Damage or loss of brain cells and impaired neurochemistry, neurogenesis, and synaptic and
nonsynaptic plasticity of the brain lead to dementia in neurodegenerative diseases, such as …

[HTML][HTML] Aducanumab—hope or disappointment for Alzheimer's disease

K Wojtunik-Kulesza, M Rudkowska… - International Journal of …, 2023 - mdpi.com
In June 2021, the world was informed about a new drug for Alzheimer's disease approved
by the FDA. Aducanumab (BIIB037, ADU), being a monoclonal antibody IgG1, is the newest …

Guidelines on the Use of therapeutic apheresis in clinical practice–Evidence‐Based approach from the Writing Committee of the American Society for Apheresis: The …

L Connelly‐Smith, CR Alquist, NA Aqui… - Journal of clinical …, 2023 - Wiley Online Library
Abstract The American Society for Apheresis (ASFA) Journal of Clinical Apheresis (JCA)
Special Issue Writing Committee is charged with reviewing, updating, and categorizing …

[HTML][HTML] Multifunctional nanoparticle-mediated combining therapy for human diseases

X Li, X Peng, M Zoulikha, GF Boafo, KT Magar… - … and Targeted Therapy, 2024 - nature.com
Combining existing drug therapy is essential in developing new therapeutic agents in
disease prevention and treatment. In preclinical investigations, combined effect of certain …

[HTML][HTML] Photobiomodulation in Alzheimer's disease—A complementary method to state-of-the-art pharmaceutical formulations and nanomedicine?

LM Ailioaie, C Ailioaie, G Litscher - Pharmaceutics, 2023 - mdpi.com
Alzheimer's disease (AD), as a neurodegenerative disorder, usually develops slowly but
gradually worsens. It accounts for approximately 70% of dementia cases worldwide, and is …

[HTML][HTML] Δ8-THC Protects against Amyloid Beta Toxicity Modulating ER Stress In Vitro: A Transcriptomic Analysis

A Gugliandolo, S Blando, S Salamone… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) represents the most common form of dementia, characterized by
amyloid β (Aβ) plaques and neurofibrillary tangles (NFTs). It is characterized by …

Sesamol attenuates scopolamine-induced cholinergic disorders, neuroinflammation, and cognitive deficits in mice

D Yun, Y Wang, Y Zhang, M Jia, T Xie… - Journal of Agricultural …, 2022 - ACS Publications
Alzheimer's disease (AD) is a neurodegenerative disease, characterized by memory loss
and cognitive deficits accompanied by neuronal damage and cholinergic disorders …

Pathophysiological Aspects and Therapeutic Armamentarium of Alzheimer's Disease: Recent Trends and Future Development

BP Dave, YB Shah, KG Maheshwari… - Cellular and Molecular …, 2023 - Springer
Alzheimer's disease (AD) is the primary cause of dementia and is characterized by the death
of brain cells due to the accumulation of insoluble amyloid plaques, hyperphosphorylation of …

First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT6 Agents with a Beneficial Neuroprotective Profile against Alzheimer's Disease

P Pyka, W Haberek, M Więcek… - Journal of Medicinal …, 2024 - ACS Publications
Alzheimer's disease (AD) has a complex and not-fully-understood etiology. Recently, the
serotonin receptor 5-HT6 emerged as a promising target for AD treatment; thus, here a new …

[HTML][HTML] Detection of β-amyloid aggregates/plaques in 5xFAD mice by labelled native PLGA nanoparticles: implication in the diagnosis of Alzheimer's disease

K Govindarajan, S Kar - Journal of Nanobiotechnology, 2023 - Springer
Evidence suggests that increased level/aggregation of β-amyloid (Aβ) peptide, together with
enhanced phosphorylation/aggregation of tau protein, play a critical role in the development …