Covering: 2006 to 2017 Actinomycetes have been, for decades, one of the most important
sources for the discovery of new antibiotics with an important number of drugs and analogs …

The outbreak of antimicrobial resistance, together with the lack of newly developed
antimicrobial drugs, represents an alarming signal for both human and animal healthcare …

Researchers, clinicians and governments all recognize antimicrobial resistance as a serious
and growing threat worldwide. New antimicrobials are urgently needed, especially for …

Infections with Pseudomonas aeruginosa have become a concerning threat in hospital-
acquired infections and for cystic fibrosis patients. The major problem leading to high …

Abstract β-Lactamase inhibitors (BLIs) have played an important role in combatting β-lactam
resistance in Gram-negative bacteria, but their effectiveness has diminished with the …

Antibiotic resistance occurs when microorganisms resist the drugs used against the infection
caused by them and neutralize their effects over time using various mechanisms. These …

Bacterial lipoproteins are a subset of membrane proteins localized on either leaflet of the
lipid bilayer. These proteins are anchored to membranes through their N-terminal lipid …

Currently, drug resistance, especially against cephalosporins and carbapenems, among
gram-negative bacteria is an important challenge, which is further enhanced by the limited …

Increasing antibacterial resistance presents a major challenge in antibiotic discovery. One
attractive target in Gram-negative bacteria is the unique asymmetric outer membrane (OM) …

The transport of small molecules across membranes is essential for the import of nutrients
and other energy sources into the cell and, for the export of waste and other potentially …