Role of microbes in the development of Alzheimer's disease: state of the art–an international symposium presented at the 2017 IAGG congress in San Francisco

T Fülöp, RF Itzhaki, BJ Balin, J Miklossy… - Frontiers in …, 2018 - frontiersin.org
This article reviews research results and ideas presented at a special symposium at the
International Association of Gerontology and Geriatrics (IAGG) Congress held in July 2017 …

Alzheimer's disease: assessing the role of spirochetes, biofilms, the immune system, and amyloid-β with regard to potential treatment and prevention

HB Allen - Journal of Alzheimer's Disease, 2016 - content.iospress.com
Alzheimer's disease (AD) is an infectious disease caused by spirochetes, and these
spirochetes form biofilms, which attract the innate immune system. The innate immune …

[HTML][HTML] Photobiomodulation with near infrared light helmet in a pilot, placebo controlled clinical trial in dementia patients testing memory and cognition

MH Berman, JP Halper, TW Nichols… - Journal of neurology …, 2017 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a common, chronic expensive debilitating neurodegenerative
disease with no current treatments to prevent the physical deterioration of the brain and the …

Bacterial amyloid and DNA are important constituents of senile plaques: further evidence of the spirochetal and biofilm nature of senile plaques

J Miklossy - Journal of Alzheimer's Disease, 2016 - content.iospress.com
It has long been known that spirochetes form clumps or micro colonies in vitro and in vivo.
Cortical spirochetal colonies in syphilitic dementia were considered as reproductive centers …

Periodontitis, microbiomes and their role in Alzheimer's disease

AB Pritchard, SJ Crean, I Olsen… - Frontiers in aging …, 2017 - frontiersin.org
As far back as the eighteenth and early nineteenth centuries, microbial infections were
responsible for vast numbers of deaths. The trend reversed with the introduction of …

Alzheimer's disease: a systems view provides a unifying explanation of its development

C Grobler, M van Tongeren… - Journal of …, 2023 - content.iospress.com
Alzheimer's disease (AD) is a debilitating neurodegenerative disorder affecting 50 million
people globally. It is characterized by the presence of extracellular senile plaques and …

Can better management of periodontal disease delay the onset and progression of Alzheimer's disease?

A Harding, S Robinson, SJ Crean… - Journal of Alzheimer's …, 2017 - content.iospress.com
A risk factor relationship exists between periodontal disease and Alzheimer's disease (AD)
via tooth loss, and improved memory following dental intervention. This links the microbial …

Inflammasome involvement in Alzheimer's disease

I Olsen, SK Singhrao - Journal of Alzheimer's Disease, 2016 - content.iospress.com
Inflammasomes are responsible for the maturation of pro-inflammatory cytokines such as
interleukin (IL)-1β, IL-18, and IL-33 and activation of inflammatory cell death, pyroptosis …

Association between Alzheimer's disease and oral and gut microbiota: are pore forming proteins the missing link?

S Aguayo, CMAP Schuh, B Vicente… - Journal of Alzheimer's …, 2018 - content.iospress.com
Alzheimer's disease (AD) is a neurodegenerative condition affecting millions of people
worldwide. It is associated with cerebral amyloid-β (Aβ) plaque deposition in the brain …

A bacterial component to Alzheimer's-type dementia seen via a systems biology approach that links iron dysregulation and inflammagen shedding to disease

E Pretorius, J Bester, DB Kell - Journal of Alzheimer's Disease, 2016 - content.iospress.com
The progression of Alzheimer's disease (AD) is accompanied by a great many observable
changes, both molecular and physiological. These include oxidative stress …