Myotonic dystrophy (DM) is the most common adult muscular dystrophy, characterized by
autosomal dominant progressive myopathy, myotonia and multiorgan involvement. To date …

Neurodegenerative diseases (NDDs) originate from a loss of neurons in the central nervous
system and are severely debilitating. The incidence of NDDs increases with age, and they …

MicroRNAs (miRNAs) are short RNA molecules which bind to target mRNAs, resulting in
translational repression and gene silencing and are found in all eukaryotic cells …

Key points• The discovery of microRNAs (miRNAs) has established new mechanisms that
control health, but little is known about the regulation of skeletal muscle miRNAs in response …

Maintaining skeletal muscle function throughout the lifespan is a prerequisite for good health
and independent living. For skeletal muscle to consistently function at optimal levels, the …

Skeletal muscle injury activates adult myogenic stem cells, known as satellite cells, to initiate
proliferation and differentiation to regenerate new muscle fibers. The skeletal muscle …

Polyphenols are the most abundant antioxidants in the human diet and are widespread
constituents of fruits and beverages, such as tea, coffee, and wine. Epidemiological, clinical …

Muscle stem cell (satellite cell) activation post muscle injury is a transient and critical step in
muscle regeneration. It is regulated by physiological cues, signaling molecules, and …

Chronic kidney disease (CKD) accelerates muscle protein degradation by stimulating the
ubiquitin proteasome system through activation of the E3 ligases, Atrogin-1/MAFbx and …

Fibro-adipogenic progenitors (FAPs) are important components of the skeletal muscle
regenerative environment. Whether FAPs support muscle regeneration or promote fibro …