The diphtheria and pertussis components of diphtheria-tetanus toxoids-pertussis vaccine should be genetically inactivated mutant toxins

JB Robbins, R Schneerson, B Trollfors… - The Journal of …, 2005 - academic.oup.com
Replacement of cellular with acellular pertussis (aP) vaccines has considerably reduced the
systemic reactions observed with diphtheria-tetanus toxoids-pertussis vaccine but has not …

Toward a new vaccine for pertussis

JB Robbins, R Schneerson… - Proceedings of the …, 2014 - National Acad Sciences
To overcome the limitations of the current pertussis vaccines, those of limited duration of
action and failure to induce direct killing of Bordetella pertussis, a synthetic scheme was …

Will we have new pertussis vaccines?

C Locht - Vaccine, 2018 - Elsevier
Despite wide vaccination coverage with efficacious vaccines, pertussis is still not under
control in any country. Two types of vaccines are available for the primary vaccination series …

A randomised controlled trial with a diphtheria–tetanus–acellular pertussis (dTpa) vaccine in adults

M Van der Wielen, P Van Damme, E Joossens… - Vaccine, 2000 - Elsevier
The aim of this assessor-blinded trial was to compare the immunogenicity and reactogenicity
of a candidate diphtheria, tetanus toxoids and acellular pertussis vaccine with reduced …

A modified vaccine reduces the rate of large injection site reactions to the preschool booster dose of diphtheria-tetanus-acellular pertussis vaccine: results of a …

DW Scheifele, SA Halperin, JJ Ochnio… - The Pediatric …, 2005 - journals.lww.com
Background: Large injection site reactions commonly follow booster doses of diphtheria-
tetanus-acellular pertussis (DTaP) vaccines at 4–6 years of age. A vaccine with lower …

Effects of lowering the aluminium content of a dTpa vaccine on its immunogenicity and reactogenicity when given as a booster to adolescents

H Theeten, P Van Damme, K Hoppenbrouwers… - Vaccine, 2005 - Elsevier
As aluminium in vaccines has been associated with the incidence of local side effects
occurring after vaccination, this observer-blind randomised clinical trial was designed to …

Reactogenicity and immunogenicity at preschool age of a booster dose of two three-component diphtheria-tetanus-acellular pertussis vaccines in children primed in …

AE Tozzi, A Anemona, D Stat, P Stefanelli… - …, 2001 - publications.aap.org
Objectives. To determine the reactogenicity and immunogenicity of a fourth dose of 2 three-
component acellular pertussis vaccines combined with diphtheria-tetanus-acellular …

Recurrence of extensive injection site reactions following DTPa or dTpa vaccine in children 4–6 years old

P Quinn, M Gold, J Royle, J Buttery, P Richmond… - Vaccine, 2011 - Elsevier
Objectives The aim of this study was to compare the immunogenicity and reactogenicity of a
lower dose diphtheria, tetanus and pertussis vaccine (dTpa) with the recommended vaccine …

Immunogenicity and reactogenicity of a reduced-antigen-content diphtheria-tetanus-acellular pertussis vaccine in healthy Taiwanese children and adolescents

LM Huang, LY Chang, H Tang, HL Bock, CY Lu… - Journal of Adolescent …, 2005 - Elsevier
PURPOSE: Disease caused by Bordetella pertussis is increasingly being identified among
older children and adults in immunized populations, indicating a waning of the vaccine …

Reactogenicity and immunogenicity of reduced antigen content diphtheria–tetanus–acellular pertussis vaccine (dTpa) administered as a booster to 4–6 year-old …

P Kosuwon, B Warachit, Y Hutagalung, T Borkird… - Vaccine, 2003 - Elsevier
A trial to compare the reactogenicity and immunogenicity of a reduced antigen content
diphtheria–tetanus–acellular pertussis (dTpa) vaccine with diphtheria–tetanus–whole-cell …