[HTML][HTML] Antimicrobial protein REG3A regulates glucose homeostasis and insulin resistance in obese diabetic mice
P Gonzalez, A Dos Santos, M Darnaud… - Communications …, 2023 - nature.com
Innate immune mediators of pathogen clearance, including the secreted C-type lectins
REG3 of the antimicrobial peptide (AMP) family, are known to be involved in the regulation …
REG3 of the antimicrobial peptide (AMP) family, are known to be involved in the regulation …
[HTML][HTML] MiR-526b-3p mediates doxorubicin-induced cardiotoxicity by targeting STAT3 to inactivate VEGFA
L Zhang, L Liu, X Li - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Abstract Doxorubicin (DOX), a wide-spectrum chemotherapeutic agent, is recognized to
have cardiotoxic side effects when it is applied in hematological diseases and solid tumor …
have cardiotoxic side effects when it is applied in hematological diseases and solid tumor …
[HTML][HTML] Transcriptional signature of islet neogenesis-associated protein peptide-treated rat pancreatic islets reveals induction of novel long non-coding RNAs
A Romero, AC Heidenreich, CL Roman… - Frontiers in …, 2023 - frontiersin.org
Background Diabetes mellitus is characterized by chronic hyperglycemia with loss of β-cell
function and mass. An attractive therapeutic approach to treat patients with diabetes in a non …
function and mass. An attractive therapeutic approach to treat patients with diabetes in a non …
[HTML][HTML] Islet neogenesis associated protein (INGAP) protects pancreatic β cells from IL-1β and IFNγ-induced apoptosis
E Nano, M Petropavlovskaia, L Rosenberg - Cell Death Discovery, 2021 - nature.com
The goal of this study was to determine whether recombinant Islet NeoGenesis Associated
Protein (rINGAP) and its active core, a pentadecapeptide INGAP104–118 (Ingap-p), protect …
Protein (rINGAP) and its active core, a pentadecapeptide INGAP104–118 (Ingap-p), protect …
Resveratrol improves the therapeutic efficacy of bone marrow-derived mesenchymal stem cells in rats with severe acute pancreatitis
D Liu, G Song, Z Ma, X Geng, Y Dai, T Yang… - International …, 2020 - Elsevier
Objective Bone marrow-derived mesenchymal stem cells (BMSCs) are effective in the
treatment of severe acute pancreatitis (SAP), but their therapeutic effects could still be …
treatment of severe acute pancreatitis (SAP), but their therapeutic effects could still be …
Structural modifications of INGAP-PP present in HTD4010 peptide potentiate its effect on rat islet gene expression and insulin secretion.
Abstract Type 2 diabetes (T2D) is characterized by peripheral insulin resistance and altered
insulin secretion due to a progressive loss of β-cell mass and function. Today, most …
insulin secretion due to a progressive loss of β-cell mass and function. Today, most …
Effects of islet neogenesis associated protein depend on vascular endothelial growth factor gene expression modulated by hypoxia-inducible factor 1-alpha
Background Pharmacology has provided efficient tools to improve insulin effect/secretion but
the decrease in β-cell mass remains elusive. INGAP-PP could provide a therapeutic …
the decrease in β-cell mass remains elusive. INGAP-PP could provide a therapeutic …
A new analogue of islet neogenesis associated protein with higher structural and plasma stability
S Lynn, Y Ricardo Espinosa Silva… - Journal of …, 2021 - Taylor & Francis
Abstract Islet Neogenesis Associated Protein pentadecapeptide (INGAP-PP) increases β-
cell mass and function in experimental animals. A short clinical trial also yielded promising …
cell mass and function in experimental animals. A short clinical trial also yielded promising …
CONFERENCIA. Diabetes mellitus: magnitud del problema, su fisiopatología, diagnóstico y tratamiento
JJ Gagliardino - Revista de la Sociedad Argentina de Diabetes, 2023 - revistasad.com
Comenzaré señalando lo que Frederick Grant Banting mencionó en su discurso de
recepción del Premio Nobel por el descubrimiento de la insulina:“La hormona no es una …
recepción del Premio Nobel por el descubrimiento de la insulina:“La hormona no es una …
Liver carbohydrates metabolism: A new islet-neogenesis associated protein peptide (INGAP-PP) target
Abstract Islet-Neogenesis Associated Protein-Pentadecapeptide (INGAP-PP) increases β-
cell mass and enhances glucose and amino acids-induced insulin secretion. Our aim was to …
cell mass and enhances glucose and amino acids-induced insulin secretion. Our aim was to …