Liquid biopsy techniques and pancreatic cancer: diagnosis, monitoring, and evaluation

K Wang, X Wang, Q Pan, B Zhao - Molecular cancer, 2023 - Springer
Pancreatic cancer (PC) is one of the most common malignancies. Surgical resection is a
potential curative approach for PC, but most patients are unsuitable for operations when at …

Advances in the early diagnosis of pancreatic ductal adenocarcinoma and premalignant pancreatic lesions

R Yamada, J Tsuboi, Y Murashima, T Tanaka, K Nose… - Biomedicines, 2023 - mdpi.com
Pancreatic cancer is one of the most lethal human malignancies, in part because it is often
diagnosed at late stages when surgery and systemic therapies are either unfeasible or …

[HTML][HTML] Prognostic role of cell-free DNA biomarkers in pancreatic adenocarcinoma: A systematic review and meta–analysis

S Bunduc, N Gede, S Váncsa, V Lillik, S Kiss… - Critical Reviews in …, 2022 - Elsevier
This systematic review and meta-analysis evaluated the prognostic role of cell-free DNA
(cfDNA) in pancreatic ductal adenocarcinoma (PDAC). Eligible studies reported differences …

High somatic mutations in circulating tumor DNA predict response of metastatic pancreatic ductal adenocarcinoma to first-line nab-paclitaxel plus S-1: prospective …

L Huang, Y Lv, S Guan, H Yan, L Han, Z Wang… - Journal of Translational …, 2024 - Springer
Aims We previously showed that the nab-paclitaxel plus S-1 (NPS) regimen had promising
effects against metastatic pancreatic ducal adenocarcinoma (mPDAC), whose efficacy …

Ultrasensitive and High‐Resolution Protein Spatially Decoding Framework for Tumor Extracellular Vesicles

CA Cheng, KC Hou, CW Hsu, LC Chiang - Advanced Science, 2024 - Wiley Online Library
Proteins localized on the surface or within the lumen of tumor‐derived extracellular vesicles
(EVs) play distinct roles in cancer progression. However, quantifying both populations of …

Echoendoscopic ultrasound pancreatic adenocarcinoma diagnosis and theranostic approach: should KRAS mutation research be recommended in everyday practice …

D Béchade, LJ Palmieri, B Bonhomme… - Therapeutic …, 2024 - journals.sagepub.com
Background: The impact of KRAS mutation testing on pancreatic ductal adenocarcinoma
(PDAC) samples by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) for …

Diagnostic value of combining preoperative inflammatory markers ratios with CA199 for patients with early-stage pancreatic cancer

Y Gu, Q Hua, Z Li, X Zhang, C Lou, Y Zhang, W Wang… - BMC cancer, 2023 - Springer
Background An early diagnosis of pancreatic cancer (PC) is extremely difficult because of
the lack of sensitive liquid biopsy methods and effective biomarkers. We attempted to …

Clinical significance of tumor suppressor genes methylation in circulating tumor DNA of patients with pancreatic cancer

WP Xin, S Tu, S Yi, Y Xiong, K Fang, G Sun, W Xiao - Gene, 2024 - Elsevier
Abstract Background Circulating tumor DNA (ctDNA) has emerged as a potential diagnostic
and prognostic biomarker in various tumors. However, the role of tumor suppressor genes …

Droplet digital polymerase chain reaction detection of KRAS mutations in pancreatic FNA samples: Technical and practical aspects for routine clinical implementation

Y Mansour, M Boubaddi, T Odion, M Marty… - Cancer …, 2024 - Wiley Online Library
Background Pancreatic adenocarcinoma (PDAC) is associated with a 5‐year survival rate of
less than 6%, and current treatments have limited efficacy. The diagnosis of PDAC is mainly …

Comparison of Fine-Needle Biopsy (FNB) versus Fine-Needle Aspiration (FNA) Combined with Flow Cytometry in the Diagnosis of Deep-Seated Lymphoma

Y Yang, Aruna, B Cheng, D Xiong, D Kuang, H Cui… - Diagnostics, 2023 - mdpi.com
Evidence comparing ultrasound endoscopy-guided fine-needle biopsy (EUS-FNB) with EUS-
guided fine-needle aspiration (EUS-FNA) in deep-seated lymphoma tissue sampling is …