Skeletal muscle possesses dramatic metabolic plasticity that allows for the rapid adaptation
in cellular energy transduction to meet the demands of the organism. Obesity elicits changes …

Cardiovascular disease is the leading complication of diabetes mellitus (DM), and diabetic
cardiomyopathy (DCM) is a major cause of mortality in diabetic patients. Multiple …

Exercise training positively affects metabolic health through increased mitochondrial
oxidative capacity and improved glucose regulation and is the first line of treatment in …

Objective We compared the effects of high-intensity interval training (HIIT) and moderate-
intensity continuous training (MICT) on insulin sensitivity and other important metabolic …

Aims Mitochondria exist as a morphologically plastic network driven by cellular bioenergetic
demand. Induction of fusion and fission machinery allows the organelle to regulate quality …

Background Increased muscle mitochondrial mass is characteristic of elite professional
endurance athletes (PAs), whereas increased blood lactate levels (lactatemia) at the same …

Key points A classic unresolved issue in human integrative physiology involves the role of
exercise intensity, duration and volume in regulating skeletal muscle adaptations to training …

Introduction: Obesity and type 2 diabetes are growing health problems worldwide. The three
principal diabetogenic factors are adiposity, insulin resistance in skeletal muscle, and …

Insulin resistance precedes and predicts the onset of type 2 diabetes (T2D) in susceptible
humans, underscoring its important role in the complex pathogenesis of this disease. Insulin …

Both Roux-en-Y gastric bypass (RYGB) surgery and exercise can improve insulin sensitivity
in individuals with severe obesity. However, the impact of RYGB with or without exercise on …