Insulin resistance and obesity are associated with a reduction of mitochondrial content in
various tissues of mammals. Moreover, a reduced nitric oxide (NO) bioavailability impairs …

The mitochondrial electron transport chain (ETC) plays a central role in energy generation in
the cell. Mitochondrial dysfunctions diminish adenosine triphosphate (ATP) production and …

Insulin resistance, a harbinger of the metabolic syndrome, is a state of compromised
hormonal response resulting from the dysregulation of a wide range of insulin-controlled …

Sustained nutrient (fuel) excess, as occurs during obesity and diabetes, has been linked to
increased inflammation, impaired mitochondrial homeostasis, lipotoxicity, and insulin …

BACKGROUND. Roux-en-Y gastric bypass (RYGB) surgery causes profound weight loss
and improves insulin sensitivity (SI) in obese patients. Regular exercise can also improve SI …

Diet modulates the development of insulin resistance during aging. This includes tissue-
specific alterations in insulin signaling and mitochondrial function, which ultimately affect …

Background The exact impact of ageing on skeletal muscle phenotype and mitochondrial
and lipid content remains controversial, probably because physical activity, which greatly …

Mounting evidence suggests a role for mitochondrial dysfunction in the pathogenesis of
many diseases, including type 2 diabetes, aging, and ovarian failure. Because of the central …

Objectives Adequate muscle perfusion supports the transport of nutrients, oxygen and
hormones into muscle fibers. Aging is associated with a substantial decrease in skeletal …

Context and Objective The myokine irisin has been proposed to regulate energy
homeostasis. Little is known about its association with metabolic parameters and especially …