Background: The effect of liver metastases on the efficacy of immune checkpoint inhibitors
(ICIs) remains inconsistent and controversial. The aim of this study was to explore the …

Glioblastoma is the most common malignant primary brain tumor in adults. Thalidomide is a
vascular endothelial growth factor inhibitor that demonstrates antiangiogenic activity, and …

ERBB2 amplification is one of the most important and mature targets for HER2-targeted drug
therapy. Somatic mutations of ERBB2 in the tyrosine kinase domain have been studied …

Simple Summary Cereblon (CRBN) is a direct binding target of immunomodulatory drugs
(IMiDs) that are commonly used to treat multiple myeloma (MM). Many patients with MM …

In this study, we prepared a bionic nanosystem of trastuzumab-functionalized SK-BR-3 cell
membrane hybrid liposome-coated pyrotinib (Ptb-M-Lip-Her) for the treatment of HER2 …

Simple Summary Human epidermal growth factor receptors (HERs) are present in our body
and are responsible for regulating cell growth. When there is an overexpression of …

There is uncertainty regarding the usefulness of CDK4/6-inhibitor-based therapy for
hormone receptor positive (HR+), human epidermal grow factor receptor 2 negative …

Pyrotinib is a novel epidermal growth factor receptor/human epidermal growth factor
receptor-2 (HER2) tyrosine kinase inhibitor that exhibited clinical efficacy in patients with …

Aim: To investigate the efficacy and safety of adjuvant EGFR tyrosine kinase inhibitors for
resected EGFR-mutated non-small-cell lung cancer. Materials & methods: Eligible phase II/III …

目的: 肺癌作为一种常见的恶性肿瘤, 是肿瘤患者死亡的主要原因之一. 近年来,
许多研究报道了靶向及免疫治疗在HER2 阳性非小细胞肺癌(NSCLC) 中的疗效. 然而 …