[HTML][HTML] Therapeutic targets of renin-angiotensin system in ocular disorders

R Choudhary, MS Kapoor, A Singh… - Journal of current …, 2017 - Elsevier
Purpose To review current literature on the renin-angiotensin system (RAS)-mediated
pathogenic mechanisms and therapeutic targets in ocular diseases. Methods A …

[HTML][HTML] Many faces of renin-angiotensin system-focus on eye

M Holappa, H Vapaatalo… - The open ophthalmology …, 2017 - ncbi.nlm.nih.gov
The renin-angiotensin system (RAS), that is known for its role in the regulation of blood
pressure as well as in fluid and electrolyte homeostasis, comprises dozens of angiotensin …

[HTML][HTML] Pathogenesis of uveitic glaucoma

D Kalogeropoulos, VCT Sung - Journal of current glaucoma …, 2018 - ncbi.nlm.nih.gov
Uveitic glaucoma consists one of the most serious complications of intraocular inflammation
and, despite its rarity, is considered as one of the leading causes of preventable loss of …

Angiotensins as therapeutic targets beyond heart disease

DG Passos-Silva, E Brandan, RAS Santos - Trends in Pharmacological …, 2015 - cell.com
The renin–angiotensin system (RAS) plays a pivotal role in cardiovascular and hydro-
electrolyte homeostasis. Blockade of the RAS as a therapeutic strategy for treating …

The pathogenesis of raised intraocular pressure in uveitis

AJ Baneke, KS Lim, M Stanford - Current eye research, 2016 - Taylor & Francis
Aim: To analyze current understanding of the factors that contribute to raised intraocular
pressure (IOP) in patients with uveitis. Methods: A pubmed literature review was carried out …

Angiotensin II and Angiotensin Receptors 1 and 2—Multifunctional System in Cells Biology, What Do We Know?

M Ziaja, KA Urbanek, K Kowalska… - Cells, 2021 - mdpi.com
For years, the renin-angiotensin system (RAS) has been perceived as a system whose role
is to primarily modulate the functioning of the cardiovascular system. Years of research into …

Identifying new drugs and targets to treat rapidly elevated intraocular pressure for angle closure and secondary glaucomas to curb visual impairment

NA Sharif - Experimental eye research, 2023 - Elsevier
A multitude of pharmacological compounds have been shown to lower and control
intraocular pressure (IOP) in numerous species of animals and human subjects after topical …

Association of systemic medication use with intraocular pressure in a multiethnic Asian population: the Singapore Epidemiology of Eye Diseases Study

H Ho, Y Shi, J Chua, YC Tham, SH Lim… - JAMA …, 2017 - jamanetwork.com
Importance There is limited understanding of the associations between systemic medication
use and intraocular pressure (IOP) in the general population. Objective To examine the …

The ocular renin–angiotensin system: a therapeutic target for the treatment of ocular disease

MJ Giese, RC Speth - Pharmacology & therapeutics, 2014 - Elsevier
The renin–angiotensin system (RAS) is most well-known for its role in regulation and
dysregulation of blood pressure as well as fluid and electrolyte homeostasis. Due to its …

Local ocular renin–angiotensin–aldosterone system: Any connection with intraocular pressure? A comprehensive review

M Holappa, H Vapaatalo, A Vaajanen - Annals of Medicine, 2020 - Taylor & Francis
The renin–angiotensin system (RAS) is one of the oldest and most extensively studied
human peptide cascades, well-known for its role in regulating blood pressure. When …