Background To overcome the drawbacks of traditional therapy for corneal
neovascularization (CNV), we evaluated the efficacy of polyethylene glycol (PEG) …

A significant challenge to current cancer drug treatment is mode of delivery, both in terms of
efficacy and off-target toxicity to healthy tissues. To overcome this, drug localisation using a …

Synthetic polypeptides are biocompatible and biodegradable macromolecules whose
composition and architecture can vary over a wide range. Their unique ability to form …

Sinomenine (SIN) is an effective anti-inflammatory agent, but its therapeutic efficacy is
limited by its short half-life and the high dosage required. Tissue-specific strategies have the …

Supramolecular assembly of short peptides is a crucial process and has shown numerous
potential applications as biomaterials. In the present work, the hydrogelation process of …

Bioinspired self-assembly is a bottom-up strategy enabling biologically sophisticated
nanostructured biogels that can mimic natural tissue. Self-assembling peptides (SAPs) …

As bioactive molecules, peptides and proteins are essential in living organisms, including
animals and humans. Defects in their function lead to various diseases in humans …

Combination therapies based on immune checkpoint blockade (ICB) are currently the
mainstay of cancer treatment, in which the synergetic delivery of multiple drugs is the …

The self-assembling of small peptides not only leads to the formation of intriguing
nanoarchitectures, but also generates materials with unexpected functional properties …

The effective delivery of nucleic acid therapeutics into tumor cells is of great importance in
terms of cancer gene therapy. Successful application of siRNAs is restricted by the …