Exome sequencing and whole genome sequencing (ES/WGS) present patients and
research participants with the opportunity to benefit from a broad scope of genetic results of …

The debate about how to manage individual research results and incidental findings in
genetic and genomic research has focused primarily on what information, if any, to offer …

Biobanks act as the custodians for the access to and responsible use of human biological
samples and related data that have been generously donated by individuals to serve the …

The duty to warn genetically at-risk relatives of patients is one of the most misunderstood
legal and ethical issues affecting clinical genetics. The legal doctrines are often associated …

A biobank is an entity that collects, processes, stores, and distributes biospecimens and
relevant data for use in basic, translational, and clinical research. Biobanking of high-quality …

In populations that have not been selected for family history of disease, it is unclear how
commonly pathogenic variants (PVs) in disease-associated genes for rare Mendelian …

Background—Massively parallel sequencing to identify rare variants is widely practiced in
medical research and in the clinic. Genome and exome sequencing can identify the genetic …

Personalized medicine can be defined broadly as a model of healthcare that is predictive,
personalized, preventive and participatory. Two US President's Council of Advisors on …

The rapid growth of next-generation genetic sequencing has prompted debate about the
responsibilities of researchers toward genetic incidental findings. Assuming there is a duty to …

The EuroBioBank (EBB) network (www. eurobiobank. org) is the first operating network of
biobanks in Europe to provide human DNA, cell and tissue samples as a service to the …