Organization of the ER–Golgi interface for membrane traffic control

F Brandizzi, C Barlowe - Nature reviews Molecular cell biology, 2013 - nature.com
Coat protein complex I (COPI) and COPII are required for bidirectional membrane trafficking
between the endoplasmic reticulum (ER) and the Golgi. While these core coat machineries …

Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis

T Kirchhausen, E Macia, HE Pelish - Methods in enzymology, 2008 - Elsevier
The large GTPase dynamin is essential for clathrin‐dependent coated‐vesicle formation.
Dynasore is a cell‐permeable small molecule that inhibits the GTPase activity of dynamin1 …

[PDF][PDF] ER-to-Golgi protein delivery through an interwoven, tubular network extending from ER

AV Weigel, CL Chang, G Shtengel, CS Xu, DP Hoffman… - Cell, 2021 - cell.com
Cellular versatility depends on accurate trafficking of diverse proteins to their organellar
destinations. For the secretory pathway (followed by approximately 30% of all proteins), the …

The ER–Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis

L Ge, D Melville, M Zhang, R Schekman - elife, 2013 - elifesciences.org
Autophagy is a catabolic process for bulk degradation of cytosolic materials mediated by
double-membraned autophagosomes. The membrane determinant to initiate the formation …

Role of Escherichia coli Curli Operons in Directing Amyloid Fiber Formation

MR Chapman, LS Robinson, JS Pinkner, R Roth… - Science, 2002 - science.org
Amyloid is associated with debilitating human ailments including Alzheimer's and prion
diseases. Biochemical, biophysical, and imaging analyses revealed that fibers produced by …

Immune control of tuberculosis by IFN-γ-inducible LRG-47

JD MacMicking, GA Taylor, JD McKinney - Science, 2003 - science.org
Interferon-γ (IFN-γ) provides an essential component of immunity to tuberculosis by
activating infected host macrophages to directly inhibit the replication of Mycobacterium …

Homotypic fusion of ER membranes requires the dynamin-like GTPase atlastin

G Orso, D Pendin, S Liu, J Tosetto, TJ Moss, JE Faust… - Nature, 2009 - nature.com
Establishment and maintenance of proper architecture is essential for endoplasmic
reticulum (ER) function. Homotypic membrane fusion is required for ER biogenesis and …

COPII collar defines the boundary between ER and ER exit site and does not coat cargo containers

O Shomron, I Nevo-Yassaf, T Aviad, Y Yaffe… - Journal of Cell …, 2021 - rupress.org
COPII and COPI mediate the formation of membrane vesicles translocating in opposite
directions within the secretory pathway. Live-cell and electron microscopy revealed a novel …

Noncanonical autophagy at ER exit sites regulates procollagen turnover

S Omari, E Makareeva… - Proceedings of the …, 2018 - National Acad Sciences
Type I collagen is the main component of bone matrix and other connective tissues.
Rerouting of its procollagen precursor to a degradative pathway is crucial for osteoblast …

[图书][B] The liver: biology and pathobiology

IM Arias, HJ Alter, JL Boyer, DE Cohen, DA Shafritz… - 2020 - books.google.com
Bridging the gap between basic scientific advances and the understanding of liver disease—
the extensively revised new edition of the premier text in the field. The latest edition of The …