Hereditary spastic paraplegias (HSPs) are a diverse group of neurodegenerative diseases
that are characterized by axonopathy of the corticospinal motor neurons. A mutation in the …

Virus replication can cause extensive rearrangement of host cell cytoskeletal and membrane
compartments leading to the “cytopathic effect” that has been the hallmark of virus infection …

In this review we will focus on the recent advances in how coiled-coil proteins of the golgin
family give identity and structure to the Golgi apparatus in animal cells. A number of recent …

The endomembrane system of eukaryotic cells uses membrane-enclosed carriers to move
diverse macromolecules among different membrane-bound compartments, a requirement …

Cells mitigate ER stress through the unfolded protein response (UPR). Here, we report
formation of ER whorls as an effector mechanism of the ER stress response. We found that …

The Golgi apparatus is a universal feature of eukaryotes, carrying out the key functions of
processing, sorting and trafficking of newly synthesized membrane and secretory proteins …

The pathogen Brucella abortus resides inside macrophages within a unique, replication-
permissive organelle that is derived from the endoplasmic reticulum (ER). Although …

Communication between compartments of the exocytic and endocytic pathways in
eukaryotic cells involves transport carriers—vesicles and tubules—that mediate the vectorial …

Two models have been put forward to explain the growth of new Golgi during the cell cycle.
The first suggests that a new Golgi grows out of the endoplasmic reticulum by de novo …

Membrane proteins exit the endoplasmic reticulum (ER) in COPII-transport vesicles. ER
export is a selective process in which transport signals present in the cytoplasmic tail (CT) of …