ADP-ribosylation factor (ARF) mediated recruitment of COPI to membranes plays a central
role in transport between the endoplasmic reticulum (ER) and the Golgi. The activation of …

Many viruses modify cellular processes for their own benefit. The enterovirus 3A protein
inhibits endoplasmic reticulum (ER)-to-Golgi transport, a function previously suggested to be …

The saga of fluorescence recovery after photobleaching (FRAP) illustrates how disparate
technical developments impact science. Starting with the classic 1976 Axelrod et al. work in …

Many intracellular pathogens exploit host secretory trafficking to support their intracellular
cycle, but knowledge of these pathogenic processes is limited. The bacterium Brucella …

The Golgi apparatus contains thousands of different types of integral and peripheral
membrane proteins, perhaps more than any other intracellular organelle. To understand …

Duplication of the single Golgi apparatus in the protozoan parasite Trypanosoma brucei has
been followed by tagging a putative Golgi enzyme and a matrix protein with variants of GFP …

Historically, Drosophila has been a model organism for studying molecular and
developmental biology leading to many important discoveries in this field. More recently, the …

A full mechanistic understanding of how secretory cargo proteins are exported from the
endoplasmic reticulum for passage through the early secretory pathway is essential for us to …

Rab7b is a recently identified member of the Rab GTPase protein family and has high
similarity to Rab7. It has been reported that Rab7b is lysosome associated, that it is involved …

The small GTPase Rab1b is essential for endoplasmic reticulum (ER) to Golgi transport, but
its exact function remains unclear. We have examined the effects of wild-type and three …