C1q+ macrophages: passengers or drivers of cancer progression
M Revel, C Sautès-Fridman, WH Fridman… - Trends in Cancer, 2022 - cell.com
The omics era made possible the quest for efficient markers for cancer progression and
revealed that macrophage populations are much more complex than just the M1/M2 …
revealed that macrophage populations are much more complex than just the M1/M2 …
Osteopontin in cancer: mechanisms and therapeutic targets
Y Kariya, Y Kariya - International Journal of Translational Medicine, 2022 - mdpi.com
Despite significant advances in the understanding of cancer biology, cancer is still a leading
cause of death worldwide. Expression of the tumor microenvironment component …
cause of death worldwide. Expression of the tumor microenvironment component …
A senescence-based prognostic gene signature for colorectal cancer and identification of the role of SPP1-positive macrophages in tumor senescence
S Yu, M Chen, L Xu, E Mao, S Sun - Frontiers in immunology, 2023 - frontiersin.org
Background Senescence is significantly associated with cancer prognosis. This study aimed
to construct a senescence-related prognostic model for colorectal cancer (CRC) and to …
to construct a senescence-related prognostic model for colorectal cancer (CRC) and to …
Single‐cell landscape highlights heterogenous microenvironment, novel immune reaction patterns, potential biomarkers and unique therapeutic strategies of cervical …
J Qiu, X Qu, Y Wang, C Guo, B Lv, Q Jiang… - Advanced …, 2023 - Wiley Online Library
Cervical adenocarcinomas (ADCs), including human papillomavirus (HPV)‐associated
(HPVA) and non‐HPVA (NHPVA), though exhibiting a more malignant phenotype and …
(HPVA) and non‐HPVA (NHPVA), though exhibiting a more malignant phenotype and …
Interactions between MFAP5+ fibroblasts and tumor-infiltrating myeloid cells shape the malignant microenvironment of colorectal cancer
Z Peng, Z Ren, Z Tong, Y Zhu, Y Zhu, K Hu - Journal of translational …, 2023 - Springer
Background The therapeutic targeting of the tumor microenvironment (TME) in colorectal
cancer (CRC) has not yet been fully developed and utilized because of the complexity of the …
cancer (CRC) has not yet been fully developed and utilized because of the complexity of the …
Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironment
The initiation and progression of cancer are intricately linked to the tumor microenvironment
(TME). Understanding the function of specific cancer-TME interactions poses a major …
(TME). Understanding the function of specific cancer-TME interactions poses a major …
An integrative analysis of single-cell and bulk transcriptome and bidirectional mendelian randomization analysis identified C1Q as a novel stimulated risk gene for …
HK Cui, CJ Tang, Y Gao, ZA Li, J Zhang… - Frontiers in …, 2023 - frontiersin.org
Background The role of complement component 1q (C1Q) related genes on human
atherosclerotic plaques (HAP) is less known. Our aim is to establish C1Q associated hub …
atherosclerotic plaques (HAP) is less known. Our aim is to establish C1Q associated hub …
Single-cell RNA sequencing of cervical exfoliated cells reveals potential biomarkers and cellular pathogenesis in cervical carcinogenesis
B Sheng, S Pan, M Ye, H Liu, J Zhang, B Zhao… - Cell Death & …, 2024 - nature.com
Cervical cancer (CC) is a common gynecological malignancy. Despite the current screening
methods have been proved effectively and significantly decreased CC morbidity and …
methods have been proved effectively and significantly decreased CC morbidity and …
Dissecting Intra-Tumoral Changes Following Immune Checkpoint Blockades in Intrahepatic Cholangiocarcinoma via Single-Cell Analysis
BY Sun, C Zhou, RY Guan, G Liu, ZF Yang… - Frontiers in …, 2022 - frontiersin.org
Purpose To dissect the tumor ecosystem following immune checkpoint blockades (ICBs) in
intrahepatic cholangiocarcinoma (ICC) at a single-cell level. Methods Single-cell RNA …
intrahepatic cholangiocarcinoma (ICC) at a single-cell level. Methods Single-cell RNA …
Thrombin cleavage of osteopontin and the host anti-tumor immune response
Simple Summary Osteopontin (OPN) is a protein produced by immune cells, as well as
many other cell types including tumor cells, that is highly modified with sugars and …
many other cell types including tumor cells, that is highly modified with sugars and …