Key mediators in the immunopathogenesis of allergic asthma

S Hall, DK Agrawal - International immunopharmacology, 2014 - Elsevier
Asthma is described as a chronic inflammatory disorder of the conducting airways. It is
characterized by reversible airway obstruction, eosinophil and Th2 infiltration, airway hyper …

In vitro and ex vivo models of human asthma

C Blume, DE Davies - European journal of pharmaceutics and …, 2013 - Elsevier
Asthma is an inflammatory disorder of the conducting airways which undergo distinct
structural and functional changes leading to non-specific bronchial hyperresponsiveness …

Animal models of asthma: reprise or reboot?

K Mullane, M Williams - Biochemical pharmacology, 2014 - Elsevier
Animal models of disease represent the pinnacle of hierarchical research efforts to validate
targets and compounds for therapeutic intervention. Yet models of asthma, particularly in the …

Translational value of animal models of asthma: challenges and promises

S Sagar, H Akbarshahi, L Uller - European journal of pharmacology, 2015 - Elsevier
Asthma is a heterogeneous disease in which various environmental stimuli as well as
different genes, cell types, cytokines and mediators are implicated. This chronic …

The importance of eosinophil, platelet and dendritic cell in asthma

SS Athari, SM Athari - Asian Pacific Journal of Tropical Disease, 2014 - Elsevier
Asthma is a syndrome of variable airflow obstruction. It is characterized pathologically by
bronchial inflammation and remodeling changes. Eosinophil infiltrate in asthma and a …

Neuronal modulation of airway and vascular tone and their influence on nonspecific airways responsiveness in asthma

BJ Canning, A Woo, SB Mazzone - Journal of allergy, 2012 - Wiley Online Library
The autonomic nervous system provides both cholinergic and noncholinergic neural inputs
to end organs within the airways, which includes the airway and vascular smooth muscle …

The increasing challenge of discovering asthma drugs

K Mullane - Biochemical Pharmacology, 2011 - Elsevier
The prevalence of asthma continues to rise. Current drugs provide symptomatic relief to
some, but not all, patients. Despite the need for new therapeutics, and a huge research …

Pendrin function in airway epithelia

C Nofziger, S Dossena, S Suzuki, K Izuhara… - Cellular Physiology and …, 2011 - karger.com
The expression and function of the anion exchanger pendrin (SLC26A4) was thought to be
limited mainly to the inner ear, kidney and thyroid. Recent data indicates that pendrin is also …

Horses with pasture asthma have airway remodeling that is characteristic of human asthma

CR Ferrari, J Cooley, N Mujahid, LR Costa… - Veterinary …, 2018 - journals.sagepub.com
Severe equine asthma, formerly recurrent airway obstruction (RAO), is the horse counterpart
of human asthma, affecting horses maintained indoors in continental climates. Equine …

The immunotherapeutic role of bacterial lysates in a mouse model of asthma

C Liu, R Huang, R Yao, A Yang - Lung, 2017 - Springer
Introduction Asthma is the most common chronic lower respiratory disease in childhood
throughout the world. Recurrent respiratory tract infections in young children, especially viral …