More than a century of research on the renin-angiotensin system (RAS) has uncovered the
widespread involvement of angiotensin II (Ang II) in the pathophysiology of cardiovascular …

The nonosmotic release of arginine vasopressin, concurrent with the activation of the
sympathetic nervous system and renin-angiotensin-aldosterone system, is thought to …

Ang II type 1 (AT1) receptors activate both conventional heterotrimeric G protein–dependent
and unconventional G protein–independent mechanisms. We investigated how these …

Objective This prospective, randomised, open-label, blinded-endpoint study was to compare
the effects of the angiotensin II (Ang II) AT1 receptor antagonist valsartan with those of the …

Epithelial-mesenchymal transitions (EMTs) are believed to play a role in invasion and
metastasis of many types of tumors. In this issue of the JCI, Chen et al. show that a gene that …

Abstract Angiotensin-(1–9)[Ang-(1–9)] is a peptide of the non-canonical renin-angiotensin
system (RAS) synthesized from angiotensin I by the monopeptidase angiotensin-converting …

Based on preclinical and clinical findings, zofenopril appears to be an angiotensin-
converting enzyme (ACE) inhibitor with high potency, significant tissue selectivity and a long …

A microwave-enhanced copper-catalyzed protocol for N-arylation using water as the solvent
is reported. This fast transformation allows the reaction between various amino acids or …

Objectives To investigate the possible interactions between serum cholesterol levels and the
renin–angiotensin system on the development of stable hypertension in subjects with high …

Angiotensin-converting enzyme inhibitors are extensively used to improve clinical outcome
of patients with several cardiovascular diseases. Zofenopril proved to be very effective in …