Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies

S Paul, E Candelario-Jalil - Experimental neurology, 2021 - Elsevier
Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review

J Zeng, T Bao, K Yang, X Zhu, S Wang… - Frontiers in …, 2023 - frontiersin.org
Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and
oxidative stress play important roles in various complex mechanisms of IS. In particular, the …

Ischemic stroke and mitochondria: mechanisms and targets

SS Andrabi, S Parvez, H Tabassum - Protoplasma, 2020 - Springer
Stroke is one of the main causes of mortality and disability in most countries of the world.
The only way of managing patients with ischemic stroke is the use of intravenous tissue …

[HTML][HTML] Decreased lymphocyte-to-monocyte ratio predicts poor prognosis of acute ischemic stroke treated with thrombolysis

H Ren, L Han, H Liu, L Wang, X Liu… - Medical science monitor …, 2017 - ncbi.nlm.nih.gov
Background Our previous study found that lower lymphocyte-to-monocyte ratio (LMR) is an
independent risk factor of clinical outcome of acute ischemic stroke (AIS). However, whether …

Cerebral ischemic postconditioning plays a neuroprotective role through regulation of central and peripheral glutamate

J You, L Feng, M Xin, D Ma… - BioMed Research …, 2018 - Wiley Online Library
Following cerebral ischemia/reperfusion (I/R) injury, a series of pathophysiological
processes are stimulated in both the central nervous system (CNS) and the periphery …

The role of hypernitrosylation in the pathogenesis and pathophysiology of neuroprogressive diseases

G Morris, K Walder, AF Carvalho, SJ Tye… - Neuroscience & …, 2018 - Elsevier
There is a wealth of data indicating that de novo protein S-nitrosylation in general and
protein transnitrosylation in particular mediates the bulk of nitric oxide signalling. These …

Mitophagy in the hippocampus is excessive activated after cardiac arrest and cardiopulmonary resuscitation

Y Huang, X Gao, X Zhou, B Xie, Y Zhang, J Zhu… - Neurochemical …, 2020 - Springer
This study examined the activation of mitophagy following cardiac arrest (CA) and
cardiopulmonary resuscitation (CPR) and the relationship between the change with time …

HMG-CoA reductase inhibitors relieve endoplasmic reticulum stress by autophagy inhibition in rats with permanent brain ischemia

T Zhang, D Lu, W Yang, C Shi, J Zang, L Shen… - Frontiers in …, 2018 - frontiersin.org
Exploring and expanding the indications of common clinical drugs, such as statins, is
important to improve the prognosis of patients with permanent cerebral infarction. It has …

Conditioning-based therapeutics for aneurysmal subarachnoid hemorrhage–A critical review

S Pugazenthi, AJ Norris, DC Lauzier… - Journal of Cerebral …, 2024 - journals.sagepub.com
Aneurysmal subarachnoid hemorrhage (SAH) carries significant mortality and morbidity,
with nearly half of SAH survivors having major cognitive dysfunction that impairs their …

[HTML][HTML] Sodium/calcium exchanger as main effector of endogenous neuroprotection elicited by ischemic tolerance

G Pignataro, P Brancaccio, G Laudati, V Valsecchi… - Cell Calcium, 2020 - Elsevier
The ischemic tolerance (IT) paradigm represents a fundamental cell response to certain
types or injury able to render an organ more “tolerant” to a subsequent, stronger, insult …