Remyelination is the process of repairing damaged myelin sheaths, involving microglia,
oligodendrocyte precursor cells (OPCs), and oligodendrocytes acting. Multiple sclerosis …

Over the past three decades, many methods have been developed to evaluate levels of
biomarkers in autoimmune diseases. Early investigations have shown that some biomarkers …

Multiple sclerosis (MS) is the chronic inflammatory demyelinating disease of the CNS.
Relapsing–remitting MS (RRMS) is the most common type of MS. However, the mechanisms …

Curative therapies against autoimmune diseases are lacking. Indeed, most of the currently
available treatments are only targeting symptoms. We have developed a novel strategy for a …

High prevalence of human brain disorders necessitates development of the reliable
peripheral biomarkers as diagnostic and disease-monitoring tools. In addition to clinical …

Multiple sclerosis (MS) is a disease of the central nervous system that involves the immune
system attacking the protective covering of nerve fibers. This disease can be influenced by …

Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system
associated with chronic inflammation, demyelination, and axonal damage. MS is a highly …

Multiple sclerosis (MS) is an autoimmune and neurodegenerative disease leading to
demyelination and axonal loss. Current treatments are immunomodulatory or …

Wobbly hedgehog syndrome (WHS) has been long considered to be a myelin disease
primarily affecting the four-toed hedgehog. In this study, we have shown for the first time that …

Introduction Siponimod, a potent and selective sphingosine-1-phosphate (S1P1, 5) agonist,
is the only therapeutic agent that has shown efficacy against disability progression, decline …