The complement system was discovered at the end of the 19th century as a heat-labile
plasma component that “complemented” the antibodies in killing microbes, hence the name …

In the past 20 years, we have witnessed tremendous advances in our ability to diagnose and
treat genetic diseases of the kidney caused by complement dysregulation. Staggering …

Introduction Complement 3 glomerulopathy (C3G) is a rare inflammatory kidney disease
mediated by dysregulation of the alternative complement pathway. No targeted therapy …

Introduction The association between a change in proteinuria over time and its impact on
kidney prognosis has not been analysed in complement component 3 (C3) glomerulopathy …

Recently, the comprehensive concept of “infection-related glomerulonephritis (IRGN)” has
replaced that of postinfectious glomerulonephritis (PIGN) because of the diverse infection …

Background: C3 glomerulopathy (C3G), a rare glomerular disease mediated by alternative
complement pathway dysregulation, is associated with a high rate of recurrence and graft …

Abstract Background Barraquer-Simons syndrome (BSS) is a rare, acquired form of
lipodystrophy characterized by progressive loss of upper body subcutaneous fat, which …

C3 glomerulopathy is a rare disease, characterized by an abnormal activation of the
complement's alternative pathway that leads to the accumulation of the C3 component in the …

Monoclonal gammopathies occur secondary to a broad range of clonal B lymphocyte or
plasma cell disorders, producing either whole or truncated monoclonal immunoglobulins …

Background C3 glomerulopathy is a rare and heterogeneous complement-driven disease. It
is often challenging to accurately predict in clinical practice the individual kidney prognosis …