[HTML][HTML] Riluzole as a neuroprotective drug for spinal cord injury: from bench to bedside

N Nagoshi, H Nakashima, MG Fehlings - Molecules, 2015 - mdpi.com
Spinal cord injury (SCI) is a devastating event resulting in permanent loss of neurological
function. To date, effective therapies for SCI have not been established. With recent progress …

2018 ACC/AHA/HRS guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay: a report of the American College of …

FM Kusumoto, MH Schoenfeld, C Barrett… - Journal of the American …, 2019 - jacc.org
The recommendations listed in this guideline are, whenever possible, evidence based. An
initial extensive evidence review, which included literature derived from research involving …

Nutritional status in chronic spinal cord injury: a systematic review and meta-analysis

GJ Farkas, MA Pitot, AS Berg, DR Gater - Spinal Cord, 2019 - nature.com
Study design Systematic review and meta-analysis. Objectives The objective was to
investigate nutritional status in chronic spinal cord injury (SCI), and compare macronutrient …

Safety of autologous human schwann cell transplantation in subacute thoracic spinal cord injury

KD Anderson, JD Guest, WD Dietrich… - Journal of …, 2017 - liebertpub.com
The rationale for implantation of autologous human Schwann cells (SCs) in persons with
subacute spinal cord injury (SCI) is based on evidence that transplanted SCs are …

First-in-man intrathecal application of neurite growth-promoting anti-Nogo-A antibodies in acute spinal cord injury

K Kucher, D Johns, D Maier, R Abel… - … and Neural Repair, 2018 - journals.sagepub.com
Background. Neutralization of central nervous system neurite growth inhibitory factors, for
example, Nogo-A, is a promising approach to improving recovery following spinal cord injury …

A prospective, multicenter, phase I matched-comparison group trial of safety, pharmacokinetics, and preliminary efficacy of riluzole in patients with traumatic spinal …

RG Grossman, MG Fehlings, RF Frankowski… - Journal of …, 2014 - liebertpub.com
A prospective, multicenter phase I trial was undertaken by the North American Clinical Trials
Network (NACTN) to investigate the pharmacokinetics and safety of, as well as obtain pilot …

[HTML][HTML] Ferroptosis in acute central nervous system injuries: the future direction?

L Shen, D Lin, X Li, H Wu, C Lenahan, Y Pan… - Frontiers in cell and …, 2020 - frontiersin.org
Acute central nervous system (CNS) injuries, such as stroke, traumatic brain injury (TBI), and
spinal cord injury (SCI) present a grave health care challenge worldwide due to high …

Early decompression (< 8 h) after traumatic cervical spinal cord injury improves functional outcome as assessed by spinal cord independence measure after one year

L Grassner, C Wutte, B Klein, O Mach… - Journal of …, 2016 - liebertpub.com
There is an ongoing controversy about the optimal timing for surgical decompression after
acute traumatic cervical spinal cord injury (SCI). For this reason, we performed a …

Long-term functional outcome in patients with acquired infections after acute spinal cord injury

MA Kopp, R Watzlawick, P Martus, V Failli… - Neurology, 2017 - AAN Enterprises
Objective: To investigate whether prevalent hospital-acquired pneumonia and wound
infection affect the clinical long-term outcome after acute traumatic spinal cord injury (SCI) …

Current topics in the management of acute traumatic spinal cord injury

CD Shank, BC Walters, MN Hadley - Neurocritical care, 2019 - Springer
Acute traumatic spinal cord injury (SCI) affects more than 250,000 people in the USA, with
approximately 17,000 new cases each year. It continues to be one of the most significant …