Aspergillus fumigatus is a saprotrophic fungus; its primary habitat is the soil. In its ecological
niche, the fungus has learned how to adapt and proliferate in hostile environments. This …

The galactomannan (GM) that is produced by the human fungal pathogen Aspergillus
fumigatus is an emblematic biomarker in medical mycology. The GM is composed of two …

While establishing an invasive infection, the dormant conidia of Aspergillus fumigatus transit
through swollen and germinating stages, to form hyphae. During this morphotype transition …

The dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-
SIGN) is an innate immune C-type lectin receptor that recognizes carbohydrate-based …

During the last decade there has been a growing interest in glycoimmunology, a relatively
new research field dealing with the specific interactions of carbohydrates with the immune …

A panel of specific monoclonal antibodies (mAbs) against synthetic pentasaccharide β-d-Gal
f-(1→ 5)-[β-d-Gal f-(1→ 5)] 3-α-d-Man p, structurally related to Aspergillus fumigatus …

Great progresses have been made in the recent years in the detection of circulating
galactofuranose-bearing molecules for the diagnosis of aspergillosis. However, the test …

Methodologies to identify epitopes or ligands of the fungal cell wall polysaccharides
influencing the immune response of human pathogens have to date been imperfect. Using …

Emerging growth of antimycotic resistance among fungal pathogens stimulates the
development of corresponding vaccines and therapeutic monoclonal antibodies for active …

The cell wall of pathogenic fungi is highly important for the development of fungal infections
and is the first cellular component to interact with the host immune system. The fungal cell …