Background Because only 25% of cases of premature ovarian insufficiency (POI) have a
known etiology, the aim of this review was to summarize the associations and mechanisms …

Background Considerable interest has been gathered on the relevant impact of preventable
factors, including incorrect lifestyle and unhealthy habits, on female fertility. Smoking …

BACKGROUND Cigarette smoking is associated with lower fecundity rates, adverse
reproductive outcomes and a higher risk of IVF failures. Over the last few decades …

BACKGROUND Advanced maternal age is associated with reduced fertility and adverse
pregnancy outcomes. This review details recent developments in our understanding of the …

BACKGROUND Oocyte number is established early in life before a gradual loss of this
ovarian reserve during reproductive life until oocyte availability becomes limiting at the …

The first histological observations about the origin of the precursors of gametes termed
primordial germ cells (PGCs) in extragonadal regions and their subsequent migration into …

Maternal cigarette smoking may affect the intrauterine hormonal environment during
pregnancy and this early fetal exposure may have detrimental effects on the future trajectory …

The precise timing and sequence of changes in expression of key genes and proteins
during human sex-differentiation and onset of steroidogenesis was evaluated by whole …

This study reviews the scientific literature on the noxious effects of cigarette smoke on the
ovarian follicle, and the cumulative data on the impact of smoking on in vitro fertilization (IVF) …

STUDY QUESTION How does maternal cigarette smoking disturb development of the
human fetal ovary? SUMMARY ANSWER Maternal smoking increases fetal estrogen titres …