The bioluminescence signal generated by the luciferase-luciferin interaction, exploited for
real-time and continuous monitoring of numerous biochemical processes in living cells and …

Bioluminescence reactions are widely applied in optical in vivo imaging in the life science
and medical fields. Such reactions produce light upon the oxidation of a luciferin (substrate) …

Nullomers are the shortest strings of absent amino acid (aa) sequences in a species or
group of species. Primes are those nullomers that have not been detected in the genome of …

Multi-component bioluminescence imaging requires an expanded collection of luciferase–
luciferin pairs that emit far-red or near-infrared light. Toward this end, we prepared a new …

Firefly luciferin methyl ester is hydrolyzed by monoacylglycerol lipase MAGL, amidase
FAAH, poorly-characterized hydrolase ABHD11, and hydrolases known for S …

Melanoma is an aggressive type of skin cancer with a poor prognosis after it gets
metastasized. The early detection of malignant melanoma is critical for effective therapy …

Luciferases catalyze light-emitting reactions that produce a rainbow of colors from their
substrates (luciferins), molecular oxygen, and often additional cofactors. These …

Background Nullomers are the shortest strings of absent amino acid (aa) sequences in a
species or group of species. Primes are those nullomers that have not been detected in the …

Firefly luciferase is homologous to fatty acyl-CoA synthetases from insects that are not
bioluminescent. Here, we determined the crystal structure of the fruit fly fatty acyl-CoA …

The p16-3MR mouse model has previously been reported to effectively visualize and
eliminate senescent cells in vivo. However, we now report significant issues with this model …