Molecular typing is an essential tool to monitor Clostridium difficile infections and outbreaks
within healthcare facilities. Molecular typing also plays a key role in defining the regional …

Over the recent decades, Clostridium difficile infection (CDI) has emerged as a global public
health threat. Despite growing attention, C. difficile remains a poorly understood pathogen …

Triptolide (TP), a traditional Chinese medicine, has been reported to be effective in the
treatment of autoimmune diseases and exerting antineoplastic activity in several human …

ABSTRACT A reference library of types of Clostridium difficile has been constructed by PCR
ribotyping isolates (n= 2,030) from environmental (n= 89), hospital (n= 1,386), community …

We determined the nucleotide sequence 3.8 kb upstream and 5.2 kb downstream of the
toxin genes A and B of Clostridium difficile. Nine ORFs were discovered. Based on PCR …

Two hundred nineteen Clostridium difficile isolates from 22 serogroups were screened for
changes in the genes coding for toxin B (tcdB) and toxin A (tcdA). Parts of the toxin genes …

A HindIII restriction endonuclease analysis (REA) typing system for total genomic
Clostridium difficile DNA including a rapid and efficient method of DNA extraction and a …

Clostridium difficile produces toxins that cause inflammation, necrosis, and fluid in the
intestine and is the most important cause of nosocomial antibiotic-associated diarrhea and …

Objective: To identify environmentally safe, rapidly acting agents for killing spores of
Clostridium difficile in the hospital environment. Design: Three classic disinfectants (2 …

From January to March 1993, a suspected outbreak of antibiotic-associated diarrhea
occurred on a pediatric oncology ward of the Clinical Center Hospital at the National …