Abstract SNAREs and Rab GTPases cooperate in vesicle transport through a mechanism
yet poorly understood. We now demonstrate that the Rab5 effectors EEA1 and Rabaptin …

The rapid and efficient phagocytic clearance of apoptotic cells, termed efferocytosis, is a
critical mechanism in the maintenance of tissue homeostasis. Removal of apoptotic cells …

• Introduction• Membrane ruffling and the formation of the macropinosome• Rabs and
macropinocytosis• The fate of the macropinosome on the endocytic pathway• A role for …

The hepatocyte growth factor‐regulated tyrosine kinase substrate, Hrs, has been implicated
in intracellular trafficking and signal transduction. Hrs contains a phosphatidylinositol 3 …

The JAMM (JAB1/MPN/Mov34 metalloenzyme) motif has been proposed to provide the
active site for isopeptidase activity associated with the Rpn11/POH1 subunit of the 19S …

Hrs, an essential tyrosine kinase substrate, has been implicated in intracellular trafficking
and signal transduction pathways. The protein contains several distinctive domains …

Monosomy 7 and interstitial deletion of 7q (− 7/7q−) are well-recognized nonrandom
chromosomal abnormalities frequently found among patients with myelodysplastic …

The phosphoinositide 5‐kinase (PIKfyve) is a critical enzyme for the synthesis of PtdIns (3, 5)
P2, that has been implicated in various trafficking events associated with the endocytic …

Infections with influenza A viruses result in the activation of a variety of intracellular
signalling pathways. Recent findings suggest that in response to double‐stranded RNA …

Early endocytic membrane traffic is regulated by the small GTPase Rab5, which cycles
between GTP-and GDP-bound states as well as between membrane and cytosol. The latter …