Early endosome autoantigen localization to early endosomes is mediated by a C-terminal
region, which includes a calmodulin binding motif, a Rab5 interaction site, and a FYVE …

Specific fusion of biological membranes is a central requirement for many cellular
processes. 1 Membrane fusion involves the merging of the membranes of two different …

EEA1 is an early endosomal Rab5 effector protein that has been implicated in the docking of
incoming endocytic vesicles before fusion with early endosomes. Because of the presence …

Early endosome antigen 1 (EEA1) is 170-kDa polypeptide required for endosome fusion.
EEA1 binds to both phosphtidylinositol 3-phosphate (PtdIns3P) and to Rab5-GTP in vitro …

The adaptor protein (AP)-3 complex is a component of the cellular machinery that controls
protein sorting from endosomes to lysosomes and specialized related organelles such as …

The nervous system spread of alpha-synuclein fibrils is thought to cause Parkinson's
disease (PD) and other synucleinopathies; however, the mechanisms underlying …

Rab GTPases are central elements of the vesicular transport machinery. An emerging view
is that downstream effectors of these GTPases are multiprotein complexes that include …

Endocytic dysfunction is an early pathological change in Alzheimer's disease (AD) and
Down's syndrome (DS). Using primary fibroblasts from DS individuals, we explored the …

After internalization from the plasma membrane, activated EGF receptors (EGFRs) are
delivered to multivesicular bodies (MVBs). Within MVBs, EGFRs are removed from the …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two incurable
neurodegenerative diseases that exist on a clinical, genetic and pathological spectrum. The …