Endocytosis and endosome dynamics are controlled by proteins of the small GTPase Rab
family. Besides possible recycling routes to the plasma membrane and various organelles …

Recognition of phosphatidylinositol 3-phosphate (PtdIns (3) P) is crucial for a broad range of
cellular signaling and membrane trafficking events regulated by phosphoinositide (PI) 3 …

Many large coiled-coil proteins are being found associated peripherally with the cytoplasmic
face of the organelles of the secretory pathway. Various roles have been proposed for these …

The intimate relationship between receptor trafficking and signalling is beginning to reveal
its secrets. Receptor endocytosis provides a mechanism for attenuation of signalling by …

Studies of various membrane trafficking steps over the past year indicate that membranes
are tethered together prior to the interaction of v-SNAREs and t-SNAREs across the …

Rab5 is a small GTPase that regulates early endosome fusion. We present here the crystal
structure of the Rab5 GTPase domain in complex with a GTP analog and the C-terminal …

Early endosomes are organized in a network of vesicles shaped by cycles of fusion, fission,
and conversion to late endosomes. In yeast, endosome fusion and conversion are …

Morphine analgesic properties and side effects such as tolerance are mediated by the μ
opioid receptor (MOR) whose endocytosis is considered of primary importance for opioid …

Rab5 and Rab4 are small monomeric GTPases localized on early endosomes and function
in vesicle fusion events. These Rab proteins regulate the endocytosis and recycling or …

The biological function of receptors is determined by their appropriate trafficking through the
endosomal pathway. Following internalization, the transferrin (Tf) receptor quantitatively …