The p85α protein is best known as the regulatory subunit of class 1A PI3Ks
(phosphoinositide 3-kinases) through its interaction, stabilization and repression of p110 …

The vacuolar protein sorting (VPS) pathway of Saccharomyces cerevisiae mediates
transport of vacuolar protein precursors from the late Golgi to the lysosome-like vacuole …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two incurable
neurodegenerative diseases that exist on a clinical, genetic and pathological spectrum. The …

The FYVE domain is a small zinc binding module that recognizes phosphatidylinositol 3-
phosphate [PtdIns (3) P], a phospholipid enriched in membranes of early endosomes and …

Vacuole SNAREs, including the t-SNAREs Vam3p and Vam7p and the v-SNARE Nyv1p, are
found in a multisubunit “cis” complex on isolated organelles. We now identify the v-SNAREs …

Homotypic fusion of immature secretory granules (ISGs) gives rise to mature secretory
granules (MSGs), the storage compartment in endocrine and neuroendocrine cells for …

The AAA-ATPase p97 (also called VCP for Valosin-containing protein) is essential for a
number of cellular processes as diverse as ER-associated degradation, DNA damage …

In recent years, a large number of coiled-coil proteins localised to the Golgi apparatus have
been identified using antisera from human patients with a variety of autoimmune conditions …

Insulin stimulates glucose uptake by promoting translocation of the Glut4 glucose transporter
from intracellular storage compartments to the plasma membrane. In the absence of insulin …

We have examined the roles of the p85/p110α and hVPS34 phosphatidylinositol (PI) 3′-
kinases in cellular signaling using inhibitory isoform-specific antibodies. We raised anti …