Homotypic fusion of immature secretory granules (ISGs) gives rise to mature secretory
granules (MSGs), the storage compartment in endocrine and neuroendocrine cells for …

Regulated exocytosis was the first intracellular membrane fusion step that was suggested to
involve both Ca2+ and calmodulin. In recent years, it has become clear that calmodulin is …

Homotypic fusion between early endosomes requires the phosphatidylinositol 3-phosphate
(PI3P)-binding protein, Early Endosomal Autoantigen 1 (EEA1). We have investigated the …

The FYVE domain is a conserved protein motif characterized by its ability to bind with high
affinity and specificity to phosphatidylinositol 3-phosphate (PI (3) P), a phosphoinositide …

In the process of internalization of molecules from the extracellular milieu, a cell uses
multiple endocytic pathways, consequently generating different endocytic vesicles. These …

Protein transport in the secretory and endocytic pathways is a multistep process involving
the generation of transport carriers loaded with defined sets of cargo, the shipment of the …

Vesicle flow within the cell is responsible for the dynamic maintenance of and
communication between intracellular compartments. In addition, vesicular transport is crucial …

Abstract d‐Serine is an astrocyte‐derived regulator for N‐methyl‐d‐aspartate receptors, but
the intracellular routes of its trafficking are still largely unknown. Here, we combined confocal …

Internalization of receptors and other cell surface components is well known to occur via
clathrin-mediated endocytosis, although other less well characterized pathways are also …

Background: Some of the mechanisms underlying cell division and partitioning of the
cellular components into the daughter cells are well known. Within the endomembrane …